Constant Rate Exposure of Pregnant Hamsters to Arsenate During Early Gestation

Details

• Personal Author:
  Ferm VH ; Hanlon DP
• Description:
  We have examined the teratogenic and embryotoxic effects of constant-rate exposure of pregnant hamsters to arsenate by means of subcutaneous implants of osmotic minipumps. Different total exposure regimens were established by varying the duration of minipump implants and by varying the concentration of arsenate in the minipumps. Dams were killed on Day 13 of pregnancy, 5 days after the critical stage of organogenesis. Numbers of resorptions, dead fetuses, and living fetuses were obtained. Fetal weights, crown-rump lengths, and the incidence of malformations were recorded. Control animals were treated identically with minipumps containing demineralized water. The percentage of malformations per litter, a direct measure of teratogenesis, was dependent only upon the concentration of arsenate in the minipumps. The minimum teratogenic response was achieved with a dose of 70 micro mol/kg dam/24 hr during the critical stages of organogenesis. The embryotoxic (fetotoxic) indicators, fetal weight and crown-rump length, decreased with increases in exposure time and with increased concentrations of arsenate. The resorption rate also depended directly upon duration of exposure and concentration of arsenate in the minipump. [Description provided by NIOSH]
• Subjects:
  Animals Occupational Health Pregnancy Safety Teratogenesis
• Keywords:
  Animal Studies Arsenates Embryopathology In Utero Exposure Prenatal Exposure Teratogens Toxic Effects
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New Hampshire ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  425-432
• Volume:
  37
• Issue:
  2
• NIOSHTIC Number:
  nn:20060475
• Citation:
  Environ Res 1985 Aug; 37(2):425-432
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  1985
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c742e99319a0295ccbca1d4d70e2e33132cb141e9d82790f36e6e651d0948617a8952de106770e63599cdcac562ba51681750375646c384244519ae2e030c4cf
• Download URL:
  https://stacks.cdc.gov/view/cdc/224352/cdc_224352_DS1.pdf
• File Type:
  [PDF - 479.79 KB ]