Acrylamide Alters Oxidative Enzyme Activity in Rat Motoneurons

Details

• Personal Author:
  Goldstein BD ; Sickles DW
• Description:
  Acrylamide (ACR) produces a central-peripheral distal axonopathy, via an unknown mechanism. We have investigated the effects of ACR on the activity of enzymes responsible for the oxidation of NADH (NADH-tetrazolium reductase activity, NADH-TR) with quantitative histochemical techniques. Chronic (5- or 10-day) injection of ACR (50 mg/kg/day) resulted in a significant decrease in enzyme activity in soleus motoneurons, which normally have high NADH-TR activity. The NADH-TR activity in motoneurons with low oxidative metabolism was not significantly affected. Retrograde labeling of motoneurons with horseradish peroxidase was diminished by the acrylamide treatment. These data demonstrate an acrylamide-induced change in the oxidative metabolism of certain motoneurons; further study will determine whether oxidative metabolism is the primary site of action of ACR in producing the distal axonopathy. [Description provided by NIOSH]
• Subjects:
  Animals Enzymes Nervous System Occupational Health Oxidants Safety Toxicology
• Keywords:
  Acrylamide Animal Studies Author Keywords: Peripheral Neuropathy Enzymatic Effects Enzyme Activity Motoneuron NADH-TR Activity Neuropathy Neurotoxic Effects Oxidative Enzymes Oxidative Metabolism Oxidative Processes

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• ISSN:
  0378-4274
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  111-118
• Volume:
  26
• Issue:
  2
• NIOSHTIC Number:
  nn:20060471
• Citation:
  Toxicol Lett 1985 Aug; 26(2-3):111-118
• CAS Registry Number:
  Acrylamide (CAS RN 79-06-1)
• Federal Fiscal Year:
  1985
• Performing Organization:
  Medical College of Georgia, Augusta, Georgia
• Peer Reviewed:
  True
• Start Date:
  19840801
• Source Full Name:
  Toxicology Letters
• End Date:
  19880929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d4390896b112df1ef3faaacd9edea5bc2a3b0337e07c7ad4ca7fce0749eb83d259812b33e4625a6b1048dbeee3576cbe9b0ce5bc23683d443dfb37e0362809e4
• Download URL:
  https://stacks.cdc.gov/view/cdc/224348/cdc_224348_DS1.pdf
• File Type:
  [PDF - 441.99 KB ]