Percutaneous Absorption of Steroids: Effect of Repeated Application

Details

• Personal Author:
  Bucks DAW ; Guy RH ; Maibach HI
• Description:
  We conclude that many questions pertaining to the effect of repeated application on percutaneous absorption in humans remain unanswered. As yet, the multiple application of the chemicals studied has not revealed any obvious changes in the skin barrier or reservoir as a function of dose. This remains at odds with the reported animal model experiments. Because of the therapeutic and toxicological relevance of the repeated dose situation, resolution of the problems indicated by this research is needed. It may be suggested that human experimentation (with larger subject populations), in which more careful control of the environment of the application site is maintained (such that the entire disposition of the administered drug can be determined), represents a logical starting point for the next sequence of investigations. [Description provided by NIOSH]
• Subjects:
  Biopharmaceutics Occupational Health Safety Skin Skin Absorption Steroids
• Keywords:
  Dermal Exposures Dose Response Humans Pharmaceuticals Pharmacology Skin Absorption
• ISSN:
  0022-3549
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  74
• Issue:
  12
• NIOSHTIC Number:
  nn:20060376
• Citation:
  J Pharm Sci 1985 Dec; 74(12):1337-1339
• Contact Point Address:
  Richard H. Guy, Departments of Pharmaceutical Chemistry, Pharmacy, and Dermatology University of California San Francisco, CA 94143
• Federal Fiscal Year:
  1986
• Performing Organization:
  University of California San Francisco, San Francisco, California
• Peer Reviewed:
  False
• Start Date:
  19840928
• Source Full Name:
  Journal of Pharmaceutical Sciences
• End Date:
  19871231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:88ab51705ff7bea6cbd40d5eaf891245387e519d5315a3987c6dbf47009b8d2542802cedba3a332c22b3ab752f9e1b3400ada880f0c8a1ec42e482762b249cf5
• Download URL:
  https://stacks.cdc.gov/view/cdc/224310/cdc_224310_DS1.pdf
• File Type:
  [PDF - 312.73 KB ]