Reaction of the Mouse Liver to Kepone Exposure

Details

• Personal Author:
  Schutzmann RL ; Swartz WJ
• Description:
  Kepone (decachlorooctahydro-1,3,4-metheno-2H-cyclobuto (cd) pentalen-2-one) is a chlorinated hydrocarbon insecticide that received notoriety in 1975 when male workers were exposed to this pesticide in a production plant in Hopewell, Virginia. Major symptoms observed were nervousness, anorexia, ataxia and tremors (Epstein 1978). Oligospermia, abnormal sperm morphology and decreased sperm motility were also found in some of these workers (Cannon et al. 1979). The liver was also affected in that some of these workers presented with hepatomegaly (Lloyd, 1975). Experiments with laboratory rats fed a Kepone diet for three months revealed a significant increase in liver weight over the duration of the experiment (Cannon and Kimbrough, 1979). Since the liver is an organ important for such activities as protein synthesis, steroid metabolism and toxic compound degradation, it is necessary to ascertain the role of such a pesticide as Kepone in altering these activities. This study was designed to determine whether exposure to Kepone over a short period of time would induce an increase in liver size and/or the incorporation of Kepone and whether such factors might be reversible once Kepone exposure ceases. This data was then compared to a group receiving estradiol-17B for similar periods of time in order to determine whether the effects elicited by Kepone might be due to its estrogenic component. [Description provided by NIOSH]
• Subjects:
  Animals Insecticides Liver Occupational Exposure Occupational Health Safety
• Keywords:
  Animal Studies Chlorinated Hydrocarbon Pesticides Hepatotoxicity Hepatotoxins Kepone Liver Damage Liver Function Occupational Exposure Pesticides And Agricultural Chemicals
• ISSN:
  0007-4861
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Louisiana ; Mississippi ; OSHA Region 4 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  169-174
• Volume:
  37
• Issue:
  2
• NIOSHTIC Number:
  nn:20060284
• Citation:
  Bull Environ Contam Toxicol 1986 Aug; 37(2):169-174
• Contact Point Address:
  William J. Swartz, Department of Anatomy, Louisiana State University Medical Center, New Orleans, LA 70112
• Federal Fiscal Year:
  1986
• Performing Organization:
  Louisiana State University, School of Medicine, Department of Anatomy, New Orleans, Louisiana
• Peer Reviewed:
  True
• Start Date:
  19790401
• Source Full Name:
  Bulletin of Environmental Contamination and Toxicology
• End Date:
  19980831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0e6a15d54914b6af181f1a173502a64bf8dc0664085c96db70a6887d897f40cf1da62db11d867b42a0a66092f1af8f0e233c25c354b880a7d78e43129bd49a0e
• Download URL:
  https://stacks.cdc.gov/view/cdc/224234/cdc_224234_DS1.pdf
• File Type:
  [PDF - 378.33 KB ]