The Association Between Prenatal Exposure to Perfluoroalkyl Substances and Childhood Neurodevelopment

Details

• Personal Author:
  Herbstman J ; Kannan K ; Lederman SA ; Perera FP ; Rauh VA ; Robinson M ; Spratlen MJ ; Trasande L
• Description:
  Perfluoroalkyl substances (PFAS) were among various persistent organic pollutants suspected to have been released during the collapse of the World Trade Center (WTC) on 9/11. Evidence on the association between prenatal PFAS exposure and child neurodevelopment is limited and inconsistent. This study evaluated the association between prenatal PFAS exposure and child cognitive outcomes measured at 5 different time points in a population prenatally exposed to the WTC disaster. The study population included 302 pregnant women in the Columbia University WTC birth cohort enrolled between December 13, 2001 and June 26, 2002 at three hospitals located near the WTC site: Beth Israel, St. Vincent's, and New York University Downtown. We evaluated the association between prenatal exposure to four PFAS (perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexanesulfonic acid (PFHxS), perfluorononanoic acid (PFNA)) and child neurodevelopment measured using the Bayley Scales of Infant Development (BSID-II) at approximately 1, 2 and 3 years of age and using The Wechsler Preschool and Primary Scale of Intelligence (WPPSI) at approximately 4 and 6 years of age. Geometric mean (range) concentrations of PFAS were 6.03 (1.05, 33.7), 2.31 (0.18, 8.14), 0.43 (
• Subjects:
  Cohort Studies Environmental Exposure Environmental Pollution Nervous System Occupational Health Pregnancy Safety September 11 Terrorist Attacks Sex Characteristics Women
• Keywords:
  Author Keywords: Perfluoroalkyl Substances Children Cognitive Function Cognitive Outcomes Cohort Studies Cord Blood Environmental Pollution Per- And Polyfluoroalkyl Substances PFAS Prenatal Exposure Sex Factors World Trade Center World Trade Center Disaster WTC

  More +
• ISSN:
  0269-7491
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  263
• NIOSHTIC Number:
  nn:20060248
• Citation:
  Environ Pollut 2020 Aug; 263(Pt B):114444
• Contact Point Address:
  Miranda J. Spratlen, Department of Environmental Health Sciences, Columbia University, 722 W 168th St., Room 1105, New York, NY 10032, USA
• Email:
  mjs2376@cumc.columbia.edu
• CAS Registry Number:
  Perfluorocarbons (CAS RN 308069-13-8) ; Perfluorohexanesulfonic acid (CAS RN 355-46-4) ; Perfluorononanoic acid (CAS RN 375-95-1) ; Perfluorooctanesulfonic acid (CAS RN 1763-23-1) ; Perfluorooctanoic acid (CAS RN 335-67-1)
• Federal Fiscal Year:
  2020
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Part Number:
  B
• Start Date:
  20150701
• Source Full Name:
  Environmental Pollution
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:29b0cd34bd39dea7abcd125172e9257f5e60f7c19aca2be18f3d3539deb72ab03a24ee166ed77ffce9a249f7744c9192f0b3de6104809ce24faa68c22d4a3e6f
• Download URL:
  https://stacks.cdc.gov/view/cdc/224206/cdc_224206_DS1.pdf
• File Type:
  [PDF - 654.67 KB ]