The Association Between Perfluoroalkyl Substances and Lipids in Cord Blood

Details

• Personal Author:
  Herbstman J ; Kannan K ; Lederman SA ; Perera FP ; Robinson M ; Spratlen MJ ; Trasande L
• Description:
  Introduction: Perfluoroalkyl substances (PFAS) were among various persistent organic pollutants suspected to have been released during the collapse of the World Trade Center (WTC) on 9/11/2001. Evidence suggests that PFAS may have cardiometabolic effects, including alterations in lipid profiles. This study evaluated the association between cord blood PFAS and lipids in a population prenatally exposed to the WTC disaster. Study Population: 222 pregnant women in the Columbia University WTC birth cohort enrolled between December 13, 2001 and June 26, 2002 at hospitals located near the WTC site: Beth Israel, St. Vincent's, and New York University Downtown. Methods: We evaluated the association between 5 cord blood PFAS-perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexanesulfonic acid (PFHxS), perfluorononanoic acid (PFNA), perfluorodecane sulfonate (PFDS)-and cord blood lipids (total lipids, total cholesterol, triglycerides). Results: Median (interquartile range [IQR]) concentrations of PFAS were 6.32 (4.58-8.57), 2.46 (1.77-3.24), 0.38 (0.25-0.74), 0.66 (0.48-0.95) and 0.11 (0.09-0.16) ng/mL for PFOS, PFOA, PFNA, PFHxS, and PFDS, respectively. Median (IQR) for lipids were 59.0 (51.5-68.5) mg/dL for total cholesterol, 196.5 (170.5-221.2) mg/dL for total lipids and 33.1 (24.2-43.9) mg/dL for triglycerides. In fully adjusted models, several PFAS were associated with higher lipid levels, including evidence of a strong linear trend between triglycerides and both PFOA and PFHxS. Conclusions: Findings support previous evidence of an association between PFAS exposure and altered lipid profiles and add novel information on this relationship in cord blood, as well as for an understudied PFAS, PFDS. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Lipids Occupational Health Pregnancy Safety September 11 Terrorist Attacks Women
• Keywords:
  Author Keywords: Perfluoroalkyl Substances Cohort Studies Cord Blood Health Effects Per- And Polyfluoroalkyl Substances PFAS World Trade Center World Trade Center Disaster WTC
• ISSN:
  0021-972X
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  105
• Issue:
  1
• NIOSHTIC Number:
  nn:20058187
• Citation:
  J Clin Endocrinol Metab 2020 Jan; 105(1):dgz024
• Contact Point Address:
  Miranda J. Spratlen, Department of Environmental Health Sciences, Columbia University, 722 W 168th St,. Room 1105, New York, NY 10032
• Email:
  mjs2376@cumc.columbia.edu
• CAS Registry Number:
  Perfluorocarbons (CAS RN 308069-13-8) ; Perfluorodecanesulfonic acid (CAS RN 335-77-3) ; Perfluorohexanesulfonic acid (CAS RN 355-46-4) ; Perfluorononanoic acid (CAS RN 375-95-1) ; Perfluorooctanesulfonic acid (CAS RN 1763-23-1) ; Perfluorooctanoic acid (CAS RN 335-67-1)
• Federal Fiscal Year:
  2020
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20150701
• Source Full Name:
  Journal of Clinical Endocrinology and Metabolism
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ffdd71d21e2f9c13c5ee4e09e607986408e40db9b8f0a493a73fd4fe27a22e196a813e7631d5929c7a099325537838605b758aef43eb8a339bbdb146056fa23c
• Download URL:
  https://stacks.cdc.gov/view/cdc/221323/cdc_221323_DS1.pdf
• File Type:
  [PDF - 666.24 KB ]