Hyperthyroidism Selectively Increases Oxidative Metabolism of Slow-Oxidative Motor Units

Details

• Personal Author:
  Oblak TG ; Scholer J ; Sickles DW
• Description:
  The effects of thyroid hormone on the NADH-tetrazolium reductase activity (oxidative metabolism marker) of soleus (slow-oxidative) and tensor fascia lata (fast-glycolytic) motoneurons were determined and compared with changes in a variety of enzyme activities in the corresponding muscle fibers. Histochemical assays have demonstrated a selective and qualitative conversion in muscle fiber ATPase and quantitative increases of NADH-tetrazolium reductase (oxidative) and mitochondrial a-glycerophosphate dehydrogenase (glycolytic) activities in the soleus muscle. Paralleling the selective action upon the soleus slow muscle fibers was a selective central nervous system effect of thyroid hormone on oxidative enzymes of soleus slow-oxidative motoneurons. This indicates that either thyroid hormones act directly and specifically on slow motoneurons or that conversion of the muscle fibers by thyroid hormones produces secondary changes in the motoneuron. These data strengthen the hypothesis that oxidative enzyme activities in motoneurons are tightly matched with oxidative enzyme activities in muscle fibers. [Description provided by NIOSH]
• Subjects:
  Endocrine System Musculoskeletal System Occupational Health Safety
• Keywords:
  Hormone Activity Hormones Muscle Tissue Nervous System Oxidative Enzymes Oxidative Metabolism Thyroid Gland
• ISSN:
  0014-4886
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  90-105
• Volume:
  97
• Issue:
  1
• NIOSHTIC Number:
  nn:20060227
• Citation:
  Exp Neurol 1987 Jul; 97(1):90-105
• Contact Point Address:
  Dr. Dale W. Sickles, Department of Anatomy, Medical College of Georgia, Augusta, Georgia 30912 USA
• Federal Fiscal Year:
  1987
• Performing Organization:
  Medical College of Georgia, Augusta, Georgia
• Peer Reviewed:
  True
• Start Date:
  19840801
• Source Full Name:
  Experimental Neurology
• End Date:
  19880929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:eb96f5c66098815fa1adc2dbbad60557e7b743aee701d0fbcb2608256a59d85c61fc1fc085c0fa2bfc5b5d271a74d3e89cd251dcee27b0d5bc1e808e3e535151
• Download URL:
  https://stacks.cdc.gov/view/cdc/224195/cdc_224195_DS1.pdf
• File Type:
  [PDF - 904.67 KB ]