Ten-Year-Replicated Circadian Profiles for 36 Physiological, Serological and Urinary Variables in Healthy Men

Details

• Personal Author:
  Bird T ; DeBartolo M ; Ferrera A ; Graeber RC ; Greco J ; Halberg F ; Hrushesky WJM ; Kanabrocki EL ; Kaplan E ; Marks GE ; McCormick JB ; Nemchausky BA ; Olwin JH ; Pauly JE ; Redmond DP ; Scheving LE ; Sothern RB
• Description:
  At 3-hr intervals over a 24-hr span, 36 systemic, serologic and urinary variables were examined in 7 men in their mid 20's in the Spring of 1969, and again in the same 7 men in the Spring of 1979 under a similar chronobiologic protocol, using the same chemical and numerical analytical procedures. The variables examined for rhythms by cosinor were: vital signs-blood pressure (systolic, diastolic, pulse pressure and mean arterial pressure), heart rate, intraocular pressure (left and right), oral temperature; serum components-albumin, albumin/globulin ratio, total bilirubin, calcium, carbon dioxide, chlorides, bilirubin, cholesterol, globulin, glucose, potassium, sodium, sodium/potassium ratio, transaminase, triglycerides, total protein, urea nitrogen; and urine components-calcium, calcium/magnesium ratio, creatinine, magnesium, pH, potassium, sodium, sodium/potassium ratio, urea clearance, urea nitrogen, volume and zinc. Although all subjects appeared clinically healthy in 1969 and in 1979, certain inter-study differences were observed in a number of rhythm parameters of different variables. Statistically significant increases in mesor for the group as a whole were observed for serum Ca, cholesterol, Cl, CO2, K, Na, and while statistically significant mesor decreases for a group as a whole were noted in serum glucose and transaminase. Statistically significant increases in amplitude for the group as a whole were observed in serum chloride and urinary Na/K ratio, while statistically signficiant decreases were observed in amplitude for blood pressure, heart rate, serum albumin, A/G ratio, globulin, glucose, protein, sodium and transaminase. For the group as a whole, a statistically significant advance in acrophase was observed in serum transaminase, while a statistically significant delay in acrophase was observed for serum A/G ratio, globulin, glucose, potassium, protein, sodium and for urinary magnesium. Statistically significant by sign test, but not by cosinor, was a numerical mesor increase for urinary urea clearance, a numerical decrease in mesor for urinary zinc; a numerical amplitude decrease for serum cholesterol; and a numerical delay in acrophase for oral temperature and serum cholesterol, CO2, and globulin in all men examined. Only mesor changes in serum cholesterol and urinary Ca/Mg were positively correlated with the change in body size over the 10-year span between studies. [Description provided by NIOSH]
• Subjects:
  Circadian Rhythm Men Occupational Health Safety Urine
• Keywords:
  Biological Rhythms Blood Pressure Circadian Rhythms Physiological Effects Proteins Urine Chemistry
• ISSN:
  0742-0528
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; District of Columbia ; Illinois ; Minnesota ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  237-284
• Volume:
  5
• Issue:
  3
• NIOSHTIC Number:
  nn:20060178
• Citation:
  Chronobiol Int 1988 Jul; 5(3):237-284
• Federal Fiscal Year:
  1988
• Performing Organization:
  University of Arkansas Med Scis Ltl Rock, Little Rock, Arkansas
• Peer Reviewed:
  True
• Start Date:
  19791201
• Source Full Name:
  Chronobiology International
• End Date:
  19880301
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a52187ee3df4b16fc0ce907d9659c15cb646ce02e626dc42a1fbc71a1c30eb69f5117e6ec8612495dda93e7282beceac0f24f61e177a6a3ee4b675f006b07d96
• Download URL:
  https://stacks.cdc.gov/view/cdc/224170/cdc_224170_DS1.pdf
• File Type:
  [PDF - 1.58 MB ]