Causes and Phenotypes of Work-Related Asthma

Details

• Personal Author:
  Boschetto P ; Henneberger, Paul K. ; Maestrelli P ; Mason P ; Tarlo S
• Description:
  Work-related asthma (WRA) includes heterogeneous conditions, which have in common (i) symptoms and signs compatible with asthma and (ii) a relationship with exposures in the workplace. The types of WRA described in this review are distinguished by their etiology, comprising of work-exacerbated asthma (WEA), irritant-induced asthma (IIA), and immunologic occupational asthma (OA). There have been significant advances in the definition and characterization of the different forms of WRA by international panels of experts. The present review provides a comprehensive and updated view of the current knowledge on causes and phenotypes of WRA. Health care practitioners should consider WRA in any case of adult asthma, given that one fifth of workers with asthma report symptoms of WEA and it has been estimated that OA represents 10% to 25% of asthma in adulthood. The information provided in this review will facilitate the physician in the recognition of the different forms of WRA, since it has been established that five categories of agents are responsible for at least 60% of WEA cases and seven groups of agents are the cause of 70% of immunologic OA. In addition, there is agreement that IIA can be elicited not only by a single massive irritant exposure, but also by low/moderate repeated irritant exposures. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Occupational Disease Bronchial Asthma Exposure Prevention Respiratory Diseases Respiratory Irritants Respiratory System Respiratory System Disorders Workplace
• ISSN:
  1660-4601
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  17
• Issue:
  13
• NIOSHTIC Number:
  nn:20060137
• Citation:
  Int J Environ Res Public Health 2020 Jul; 17(13):4713
• Contact Point Address:
  Piero Maestrelli, Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy
• Email:
  piero.maestrelli@unipd.it
• Federal Fiscal Year:
  2020
• Peer Reviewed:
  True
• Source Full Name:
  International Journal of Environmental Research and Public Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:39d3e05cf0675b7396920d39ee188b048f1349801b312a3354646126b27e4c65d286d7c87de330f3bb4a73ae4926efb3ea532274285482e70a1dc80f904736ad
• Download URL:
  https://stacks.cdc.gov/view/cdc/224141/cdc_224141_DS1.pdf
• File Type:
  [PDF - 662.41 KB ]