Physicochemical Aspects of Percutaneous Penetration and Its Enhancement

Details

• Personal Author:
  Guy RH ; Hadgraft J
• Description:
  The classic diffusion model-based interpretation of percutaneous absorption is compared to a simple kinetic analysis. The physicochemical significance and the major deductions of the two approaches are shown to be in general agreement. In particular, the effect of penetrant oil/water partition coefficient on transdermal flux is consistently predicted by the two models. Diffusional and kinetic assessments of skin penetration enhancement are then shown to reveal similar dependencies upon penetrant physical chemistry. It is demonstrated that the requirements for successful promotion of a lipophilic drug's transdermal flux are quite different from those necessary for a hydrophilic penetrant. Finally, in light of published transport data and our increased comprehension of the stratum corneum barrier function, the evidence for (and significance of) different absorption paths across the stratum corneum is considered. In addition, the impact of penetrant "size" on transport is addressed. It is argued that currently held beliefs concerning (i) a putative "polar" route through the stratum corneum and (ii) the dependence of flux on molecular weight warrant considerable further attention before their unequivocal acceptance is appropriate. [Description provided by NIOSH]
• Subjects:
  Occupational Health Safety Skin Skin Absorption
• Keywords:
  Author Keywords: Percutaneous Absorption Chemicals Dermal Absorption Dermal Exposures Permeation Skin Absorption Skin Enhancement Skin Exposure Skin Penetration Transport Kinetics Transport Mechanisms

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• ISSN:
  0724-8741
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  5
• Issue:
  12
• NIOSHTIC Number:
  nn:20060075
• Citation:
  Pharm Res 1998 Dec; 5(12):753-758
• Contact Point Address:
  Jonathan Hadgraft, The Welsh School of Pharmacy, University of Wales, Cardiff, Cardiff, CF1 3XF Wales
• Federal Fiscal Year:
  1989
• Performing Organization:
  University of California San Francisco, San Francisco, California
• Peer Reviewed:
  True
• Start Date:
  19840928
• Source Full Name:
  Pharmaceutical Research
• End Date:
  19871231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:15681642ef09dbd2e9a9018f64884ec6c6317d6e68823f64b0658ac22465ff6e7a2bc0a8fa7a23c37347a349bd4d2ad68d01976e8a943f2482280eab218bfefd
• Download URL:
  https://stacks.cdc.gov/view/cdc/224103/cdc_224103_DS1.pdf
• File Type:
  [PDF - 214.55 KB ]