Determination and Metabolism of Dithiol Chelating Agents: IV. Urinary Excretion of Meso-2,3-Dimercaptosuccinic Acid and Mercaptosuccinic Acid in Rabbits Given Meso-2,3-Dimercaptosuccinic Acid

Details

• Personal Author:
  Aposhian HV ; Maiorino RM
• Description:
  The water-soluble dithiol chelating agents meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercaptopropane-l-sulfonic acid (DMPS) are becoming of increasing importance for the treatment of lead, arsenic and mercury poisoning. There is, however, a paucity of data about their metabolic transformation. Male rabbits were given DMSA (0.20 mmol/kg) i.m., and urine was collected over a 6-hr period. Monobromobimane derivatization, HPLC separation, and fluorescence detection, along with [U-14C]DMSA data, demonstrated that the total 14C found in the urine was distributed as 73% unaltered DMSA, 7% mercaptosuccinic acid and 6 and 14% of two unknowns. Electrolytic reductive treatment of the urine did not increase the urinary content of DMSA, indicating that oxidative biotransformation is not a major pathway for DMSA in the rabbit. This latter result is strikingly different from that for DMPS in rabbit. [Description provided by NIOSH]
• Subjects:
  Animals Biochemistry Energy Metabolism Occupational Health Safety Sulfhydryl Compounds
• Keywords:
  Animal Studies Chelating Agents Metabolic Effects Metal Poisoning Thiols
• ISSN:
  0006-2952
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arizona ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  38
• Issue:
  7
• NIOSHTIC Number:
  nn:20060048
• Citation:
  Biochem Pharmacol 1989 Apr; 38(7):1147-1154
• Contact Point Address:
  Dr. H. Vasken Aposhian, Department of Molecular and Cellular Biology, Biosciences West Bidg., University of Arizona, Tucson, AZ 85721, U.S.A.
• Federal Fiscal Year:
  1989
• Performing Organization:
  University of Arizona, Tucson, Arizona
• Peer Reviewed:
  True
• Start Date:
  19860101
• Source Full Name:
  Biochemical Pharmacology
• End Date:
  19880331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4e5af95c62f38b13820d362dc2c4a3fd13f20da5a862bce1732f85f2e7bfdc154fe496ac7f976c917159eac99182bae43b9230277c502d2173a9f1f2931382d4
• Download URL:
  https://stacks.cdc.gov/view/cdc/224081/cdc_224081_DS1.pdf
• File Type:
  [PDF - 832.70 KB ]