Comparison of Fecal Occult Blood Tests for Colorectal Cancer Screening in an Alaska Native Population With High Prevalence of Helicobacter pylori Infection, 2008–2012

Details

• Journal Article:
  Preventing Chronic Disease (PCD)
• Personal Author:
  Redwood, Diana ; Provost, Ellen ; Asay, Elvin ; Roberts, Diana ; Haverkamp, Donald ; Perdue, David ; Bruce, Michael G ; Sacco, Frank ; Espey, David
• Description:
  Introduction
  
  Alaska Native colorectal cancer (CRC) incidence and mortality rates are the highest of any ethnic/racial group in the United States CRC screening using guaiac-based fecal occult blood tests (gFOBT) are not recommended for Alaska Native people because of false-positive results associated with a high prevalence of Helicobacter pylori-associated hemorrhagic gastritis This study evaluated whether the newer immunochemical FOBT (iFOBT) resulted in a lower false-positive rate and higher specificity for detecting advanced colorectal neoplasia than gFOBT in a population with elevated prevalence of H pylori infection
  
  Methods
  
  We used a population-based sample of 304 asymptomatic Alaska Native adults aged 40 years or older undergoing screening or surveillance colonoscopy (April 2008–January 2012)
  
  Results
  
  Specificity differed significantly (P < 001) between gFOBT (76%; 95% CI, 71%–81%) and iFOBT (92%; 95% CI, 89%–96%) Among H pylori-positive participants (54%), specificity of iFOBT was even higher (93% vs 69%) Overall, sensitivity did not differ significantly (P = 73) between gFOBT (29%) and iFOBT (36%) Positive predictive value was 11% for gFOBT and 32% for iFOBT
  
  Conclusion
  
  The iFOBT had a significantly higher specificity than gFOBT, especially in participants with current H pylori infection The iFOBT represents a potential strategy for expanding CRC screening among Alaska Native and other populations with elevated prevalence of H pylori, especially where access to screening endoscopy is limited
  
  
• Subjects:
  Adult Colorectal Neoplasms Early Detection Of Cancer Feces Female Helicobacter Infections Helicobacter Pylori Humans Indians, North American Male Middle Aged Occult Blood Original Research

  More +
• Source:
  Prev Chronic Dis 11
• DOI:
  http://dxdoiorg/105888/pcd11130281
• ISSN:
  1545-1151
• Document Type:
  Journal Article
• Place as Subject:
  Alaska
• Location:
  Alaska
• Volume:
  11
• Collection(s):
  CDC Public Access Preventing Chronic Disease
• Main Document Checksum:
  urn:sha-512:eaee6c092f0e7ba76d77bc00d969f9dcee3a500fa508e03c2e35f3d24830d1a9071fe3571391859150682cf8b5ea5e23c8d1dc8601f5b7e2d0f56c6c4b6985ac
• Download URL:
  https://stacks.cdc.gov/view/cdc/22408/cdc_22408_DS1.pdf
• File Type:
  [PDF - 574.94 KB ]