Histocompatibility Antigens in a Population Based Silicosis Series

Details

• Personal Author:
  Danilovs JA ; Kreiss, Kathleen ; Newman, Lee S.
• Description:
  Individual susceptibility to silicosis is suggested by the lack of a uniform dose response relation and by the presence of immunological epiphenomena, such as increased antibody levels and associated diseases that reflect altered immune regulation. Human leucocyte antigens (HLA) are linked with immune response capability and might indicate a possible genetic susceptibility to silicosis. Forty nine silicotic subjects were identified from chest radiographs in a population based study in Leadville, Colorado. They were interviewed for symptoms and occupational history and gave a blood specimen for HLA-A, -B, -DR, and -DQ typing and for antinuclear antibody, immune complexes, immunoglobulins, and rheumatoid factor. Silicotic subjects had twice the prevalence of B44 (45%) of the reference population and had triple the prevalence of A29 (20%), both of which were statistically significant when corrected for the number of comparisons made. No perturbations in D-region antigen frequencies were detected. B44-positive subjects were older at diagnosis and had less dyspnoea than other subjects. A29-positive subjects were more likely to have abnormal levels of IgA and had higher levels of immune complexes. This study is the first to find significant HLA antigen excesses among a series of silicotic cases and extends earlier reported hypotheses that were based on groups of antigens of which B44 and A29 are components. [Description provided by NIOSH]
• Subjects:
  Antigens Immune System Occupational Health Safety
• Keywords:
  Dose Response Genetic Predisposition Immune Reaction Immunological Tests Immunologic Disorders Immunology Silicosis
• ISSN:
  0007-1072
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  364-369
• Volume:
  46
• Issue:
  6
• NIOSHTIC Number:
  nn:20060046
• Citation:
  Br J Ind Med 1989 Jun; 46(6):364-369
• Contact Point Address:
  Dr Kreiss, National Jewish Center, 1400 Jackson Street, Denver, CO 80206, USA
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  1989
• Performing Organization:
  National Jewish Center for Immnolgy/Respiratory Medicine, Denver, Colorado
• Peer Reviewed:
  True
• Start Date:
  19840928
• Source Full Name:
  British Journal of Industrial Medicine
• End Date:
  19870831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9739e8dcbb91f256e022ce2657536dc2213efd90e3e7983a6a39cee83838625fccbf0ceadefe7118a968d1b76b271dde24bd357ecd8c5da6bb132a16f0385f7e
• Download URL:
  https://stacks.cdc.gov/view/cdc/224079/cdc_224079_DS1.pdf
• File Type:
  [PDF - 915.83 KB ]