Indoor-Outdoor Concentrations and Correlations of PM10-Associated Mutagenic Activity in Nonsmokers’ and Asthmatics’ Homes

Details

• Personal Author:
  Colome SD ; Hsieh DPH ; Jaques P ; Kado NY ; Kleinman MT
• Description:
  The indoor-outdoor relations of mutagenic compounds associated with airborne particles less than 10 micro m aerodynamic diameter (PM10) were studied in the homes of 10 nonsmokers located in southern California. Asthmatics lived in nine of the 10 homes studied. Low-volume samplers (4 and 2 L/min) fitted with PM10 and cyclone (5-micro m nominal particle size cut) particle preselectors were used to collect 24-h air samples indoors and outdoors. In addition, three individuals carried personal samplers for 24-h periods. Filter extracts were tested for mutagenicity using a sensitive Salmonella microsuspension assay. The concentrations of particle-associated mutagens were significantly higher outdoors compared to indoors. For the PM10- and cyclone-collected samples, indoor-outdoor ratios averaged 0.46 and 0.49, respectively. There were significant correlations between indoor and outdoor mutagenicity (revertants/m3) for all samples (Spearman rank, Rs = 0.74; n = 25 pairs; p < 0.001). Further, the indoor and outdoor correlation of specific-mass mutagenic activity [revertants per unit particle mass (revertants/micro g)] was highly significant [p < 0.001; Rs = 0.90 (n = 25 pairs)]. The mutagenic activity of personal samples was very similar to the fixed-site samples collected indoors. The results support the hypothesis that mutagen composition of the indoor and outdoor particles are similar and that outdoor particles which infiltrate into homes may be a significant source of respirable mutagenic particles in the homes of nonsmokers. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollution Air Pollution, Indoor Asthma Asthma, Occupational Environmental Monitoring Mutagens Occupational Health Particulate Matter Safety
• Keywords:
  Air Pollution Air Pollution Sampling Air Sampling Indoor Air Pollution Particulates
• ISSN:
  0013-936X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; New York ; OSHA Region 2 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  28
• Issue:
  6
• NIOSHTIC Number:
  nn:20060039
• Citation:
  Environ Sci Technol 1994 Jun; 28(6):1073-1078
• Contact Point Address:
  Norman Y. Kado, Research Division, California Air Resources Board, P.O. Box 2815, Sacramento, CA 95812
• Federal Fiscal Year:
  1994
• Performing Organization:
  Mount Sinai School of Medicine, New York
• Peer Reviewed:
  True
• Start Date:
  19920701
• Source Full Name:
  Environmental Science and Technology
• End Date:
  19970630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ff1fdca6d0c75a7465c74498ee25379e0e48369943ac26fc864f8ce35e3c4ba6f57a7e285406ed3ae8172a42c33dd476fcc1b3c7e2dbfc4524a5dd1d8c42bc36
• Download URL:
  https://stacks.cdc.gov/view/cdc/224073/cdc_224073_DS1.pdf
• File Type:
  [PDF - 1.35 MB ]