Processed Meats and Risk of Childhood Leukemia (California, USA)

Details

• Personal Author:
  Bowman, Joseph D. ; Buckley JD ; London SJ ; Peters, John M. ; Preston-Martin S ; Thomas DC
• Description:
  The relation between the intake of certain food items thought to be precursors or inhibitors of N-nitroso compounds (NOC) and risk of leukemia was investigated in a case-control study among children from birth to age 10 years in Los Angeles County, California (United States). Cases were ascertained through a population-based tumor registry from 1980 to 1987. Controls were drawn from friends and by random-digit dialing. Interviews were obtained from 232 cases and 232 controls. Food items of principal interest were: breakfast meats (bacon, sausage, ham); luncheon meats (salami, pastrami, lunch meat, corned beef, bologna); hot dogs; oranges and orange juice; and grapefruit and grapefruit juice. We also asked about intake of apples and apple juice, regular and charcoal broiled meats, milk, coffee, and coke or cola drinks. Usual consumption frequencies were determined for both parents and the child. When the risks were adjusted for each other and other risk factors, the only persistent significant associations were for children's intake of hot dogs (odds ratio [OR]=9.5, 95 percent confidence interval [CI]=1.6-57.6 for 12 or more hot dogs per month, trendP=0.01), and fathers' intake of hot dogs (OR=11.0, CI=1.2-98.7 for highest intake category, trendP=0.01). There was no evidence that fruit intake provided protection. While these results are compatible with the experimental animal literature and the hypothesis that human NOC intake is associated with leukemia risk, given potential biases in the data, further study of this hypothesis with more focused and comprehensive epidemiologic studies is warranted. [Description provided by NIOSH]
• Subjects:
  Diet Epidemiology Neoplasms Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Author Keywords: Childhood Leukemia Cancer Rates Case Control Studies Children Dietary Effects Food Food Additives Hot Dogs N-nitroso Compounds Nitrites Processed Meats Risk Factors United States

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• ISSN:
  0957-5243
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Ohio ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  195-202
• Volume:
  5
• Issue:
  2
• NIOSHTIC Number:
  nn:20060006
• Citation:
  Cancer Causes Control 1994 Mar; 5(2):195-202
• Contact Point Address:
  Family and Preventive Medicine University of Southern Calif 2025 Zonal Ave Los Angeles, Calif 90033
• Federal Fiscal Year:
  1994
• Performing Organization:
  University of Southern California, Los Angeles, California
• Peer Reviewed:
  True
• Start Date:
  19820201
• Source Full Name:
  Cancer Causes and Control
• End Date:
  19870131
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5b702762c8f43c6bc25292c9ca692604d3c5071d5cf7164316ad92f0d49d9bc701843a3def5151a5795190af67b49c6140b993c24504091055b170bb752a1a4c
• Download URL:
  https://stacks.cdc.gov/view/cdc/224048/cdc_224048_DS1.pdf
• File Type:
  [PDF - 688.41 KB ]