Factors Influencing Susceptibility to Metals

Details

• Personal Author:
  Gochfeld M
• Description:
  Although the long-neglected field of human susceptibility to environmental toxicants is currently receiving renewed attention, there is only scant literature on factors influencing susceptibility to heavy metals. Genetic factors may influence the availability of sulfhydryl-containing compounds such as glutathione and metallothionein, which modify the distribution and toxicity of certain metals. Age and gender play a role in modifying uptake and distribution, although the mechanisms are often obscure. Concurrent exposure to divalent cations may enhance or reduce the toxicity of certain metals through competition for receptor-mediated transport or targets. Increasing use of biomarkers of exposure should greatly increase our understanding of the underlying distribution of susceptibility to various environmental agents. [Description provided by NIOSH]
• Subjects:
  Age Factors Environmental Exposure Metals, Heavy Occupational Health Safety Sex Characteristics
• Keywords:
  Age Factors Author Keywords: Age Cadmium Environmental Exposure Environmental Health Gender Gender Factors Genetic Factors Glutathione Heavy Metals Lead Mercury Metallothionein Susceptibility Toxic Effects Zinc

  More +
• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New Jersey ; New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  105
• NIOSHTIC Number:
  nn:20060000
• Citation:
  Environ Health Perspect 1997 Jun; 105(Suppl 4):817-822
• Contact Point Address:
  Dr. M. Gochfeld, Environmental and Occupational Health Sciences Institute, 681 Frelinghuysen Road, Piscataway, NJ 08855
• Email:
  gochfeld@eohsi.rutgers.edu
• Federal Fiscal Year:
  1997
• Performing Organization:
  Mount Sinai School of Medicine, New York
• Peer Reviewed:
  True
• Start Date:
  19920701
• Source Full Name:
  Environmental Health Perspectives
• Supplement:
  4
• End Date:
  19970630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:eff6a45cf88174b8bb81fc43b9fc57c3b23867e9f99461ea5ea6f7ed5e80d29c3ba6acf4ec831bdafabbec46549e805f788b720c42395dc89785d6a144c8b5e2
• Download URL:
  https://stacks.cdc.gov/view/cdc/224044/cdc_224044_DS1.pdf
• File Type:
  [PDF - 1.25 MB ]