Association Between Iron Deficiency and Blood Lead Level in a Longitudinal Analysis of Children Followed in an Urban Primary Care Clinic

Details

• Personal Author:
  Hu H ; Schwartz J ; Tsaih S-W ; Wright RJ ; Wright RO
• Description:
  Objective: To determine if iron deficiency (ID) is longitudinally associated with lead poisoning. Study design: Blood lead levels, hemoglobin, mean corpuscular volume (MCV), red cell distribution width (RDW), insurance status, and age were determined for 1,275 children. ID was defined as MCV <70 fl and RDW >14.5 if age was <2 years and MCV <73 fl and RDW >14.5 if age was >/=2 years. Logistic regression models were constructed by using the second-visit blood lead levels dichotomized at >/=0.48 microm/L (10 microg/dL) as the outcome. Results: The odds ratio (OR) for baseline ID predicting lead poisoning at the second visit was 4.12 (95% CI, 1.96-8.65). In the second model, using children who were iron-replete at both visits as the referent group, for children with ID at both visits, the OR for predicting lead poisoning at the second visit was 5.54 (95% CI, 2.25-13.62). For children with ID at the first visit and iron-replete at the second visit, the OR was 2.73 (95% CI, 0.90-8.27), and for children iron-replete at the first visit and ID at the second visit, the OR was 0.81 (95% CI, 0.10-6.30). Conclusions: ID is associated with subsequent lead poisoning. These data are consistent with a biological mechanism of increased lead absorption among iron deficient children. [Description provided by NIOSH]
• Subjects:
  Aging Environmental Exposure Epidemiology Ferrous Compounds Lead Men Occupational Health Risk Assessment Risk Factors Safety Women

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• Keywords:
  Age Groups Blood Lead Levels Children Exposure Levels Humans Iron Iron Compounds Lead Compounds Models Risk Factors Statistical Analysis

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• ISSN:
  0022-3476
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  9-14
• Volume:
  142
• Issue:
  1
• NIOSHTIC Number:
  nn:20059946
• Citation:
  J Pediatr 2003 Jan; 142(1):9-14
• Contact Point Address:
  Robert O.Wright, MD, The Channing Laboratory, 181 Longwood Ave, Boston, MA 02115
• CAS Registry Number:
  Iron (CAS RN 7439-89-6) ; Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2003
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20030701
• Source Full Name:
  The Journal of Pediatrics
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3509800179e68dc17c14d76d5ffb55478320e0b1b0f211ee8eb21716ca651567b4b02f69f8fa4c51eb1663f19203d865e79c6568164e1071798f4469c31595a1
• Download URL:
  https://stacks.cdc.gov/view/cdc/223999/cdc_223999_DS1.pdf
• File Type:
  [PDF - 458.82 KB ]