Association Between Hemochromatosis Genotype and Lead Exposure Among Elderly Men: The Normative Aging Study

Details

• Personal Author:
  Aro A ; Hu H ; Schwartz J ; Senter J ; Silverman EK ; Sparrow D ; Tsaih S-W ; Weiss ST ; Wright RO
• Description:
  Because body iron burden is inversely associated with lead absorption, genes associated with hemochromatosis may modify body lead burden. Our objective was to determine whether the C282Y and/or H63D hemochromatosis gene (HFE) is associated with body lead burden. Patella and tibia lead levels were measured by K X-ray fluorescence in subjects from the Normative Aging Study. DNA samples were genotyped for C282Y and H63D using polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP). A series of multivariate linear regression models were constructed with bone or blood lead as dependent variables; age, smoking, and education as independent variables; and C282Y or H63D as independent risk factors and/or effect modifiers. Of 730 subjects, 94 (13%) carried the C282Y variant and 183 (25%) carried the H63D variant. In the crude analysis, mean tibia, patella, and blood lead levels were consistently lower in carriers of either HFE variant compared with levels in subjects with wild-type genotypes. In multivariate analyses that adjusted for age, smoking, and education, having an HFE variant allele was an independent predictor of significantly lower patella lead levels (p < 0.05). These data suggest that HFE variants have altered kinetics of lead accumulation after exposure. Among elderly men, subjects with HFE variants had lower patella lead levels. These effects may be mediated by alterations in lead toxicokinetics via iron metabolic pathways regulated by the HFE gene product and body iron stores. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Education Ferrous Compounds Genetics Lead Men Occupational Health Risk Assessment Risk Factors Safety Smokers

  More +
• Keywords:
  Age Factors Deoxyribonucleic Acids DNA Exposure Limits Genes Genotype Health Effects Humans Iron Iron Compounds Lead Compounds Models Risk Factors Sampling Smoking X-ray Fluorescence Analysis

  More +
• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  112
• Issue:
  6
• NIOSHTIC Number:
  nn:20059945
• Citation:
  Environ Health Perspect 2004 May; 112 (6):746-750
• Contact Point Address:
  R.O. Wright, Division of Emergency Medicine, Children's Hospital Boston, 300 Longwood Ave., Boston, MA 02115
• Email:
  robert.wright@channing.harvard.edu
• CAS Registry Number:
  Iron (CAS RN 7439-89-6) ; Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2004
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20030701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:81bd028f2e890818b1699e62d545f222d014948c75759a4be8f9cba86d844e7bf1ce7355d2d5e00e5ac191bc6ba5ec0070ff76e2705b137a5dcfa3a5d1fe400d
• Download URL:
  https://stacks.cdc.gov/view/cdc/223998/cdc_223998_DS1.pdf
• File Type:
  [PDF - 237.03 KB ]