Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study

Details

• Personal Author:
  Hie H ; Hu H ; Litonjua A ; Perlstein T ; Schwartz J ; Sparrow D ; Weuve J ; Wright R
• Description:
  BACKGROUND: Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote functional and structural vascular disease. OBJECTIVES: We tested the hypothesis that cumulative community-level lead exposure, measured with K-X-ray fluorescence, is associated with pulse pressure in a cohort of adult men. METHODS AND RESULTS: In a cross-sectional analysis of 593 men not treated with antihypertensive medication, tibia lead was positively associated with pulse pressure (p < 0.001). Adjusting for age, race, diabetes, family history of hypertension, education, waist circumference, alcohol intake, smoking history, height, heart rate, fasting glucose, and total cholesterol-to-HDL ratio, increasing quintiles of tibia lead remained associated with increased pulse pressure (ptrend = 0.02). Men with tibia lead above the median (19.0 µg/g) had, on average, a 4.2-mmHg (95% confidence interval, 1.9-6.5) higher pulse pressure than men with tibia lead level below the median. In contrast, blood lead level was not associated with pulse pressure. CONCLUSIONS: These data indicate that lead exposure may contribute to the observed increase in pulse pressure that occurs with aging in industrialized societies. Lead accumulation may contribute to arterial aging, perhaps providing mechanistic insight into the observed association of low-level lead exposure with cardiovascular mortality. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Alcoholic Beverages Blood Body Weight Cardiovascular Diseases Cardiovascular System Education Epidemiology Hematologic Diseases Lead Men Occupational Health Race Factors Risk Assessment Risk Factors Safety Smokers

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• Keywords:
  Age Factors Age Groups Alcohol Author Keywords: Aging Blood Pressure Blood Sugar Disorders BMI Body Mass Index Body Weight Exposure Limits Heart Rate Human Humans Hypertension Lead Exposure Pulse Pressure Racial Factors Risk Factors Smoking X-ray Fluorescence Analysis

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• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  115
• Issue:
  12
• NIOSHTIC Number:
  nn:20058756
• Citation:
  Environ Health Perspect 2007 Dec; 115(12):1696-1700
• Contact Point Address:
  T.S. Perlstein, Cardiovascular Division, Brigham and Women's Hospital, 75 Francis St., A Building, 3rd Floor, Boston, MA 02115
• Email:
  tperlstein@partners.org
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2008
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f91ac554b06d3a3430f1434f91bdb480c52150900660e0a5bb64da8ef6385d7390254dd008ce0dac543813dcc0ebe1a4856719fa621222667ba67d5d7c0050ef
• Download URL:
  https://stacks.cdc.gov/view/cdc/223156/cdc_223156_DS1.pdf
• File Type:
  [PDF - 126.26 KB ]