Smoking and Cognitive Function in Parkinson’s Disease

Details

• Personal Author:
  Ascherio A ; Grodstein F ; Weisskopf MG
• Description:
  The risk of dementia among Parkinson's disease (PD) patients is greatly elevated compared to controls, yet little is known about determinants of cognitive function among PD patients. We assessed the relation between cigarette smoking prior to disease onset and later cognitive function among PD patients (n = 286) and age- and sex-matched controls (n = 1144) participating in the Nurses' Health Study and Health Professionals Follow-up Study. Both groups completed telephone-administered assessments of cognitive function. We used linear regression to calculate mean differences in cognitive test scores across smoking categories, adjusted for age, education, sex, age at onset of PD, and years since diagnosis. PD patients scored significantly worse on all tests than their matched controls. In analyses only among PD cases, but not among controls, current smokers at PD onset scored worse than never smokers on the Telephone Interview for Cognitive Status (difference = -0.82, 95% CI: -1.33, -0.30, P = 0.002) as well as on a global score combining results of all tests (difference = -0.36, 95% CI: -0.72, 0.01, P = 0.06). This difference was equivalent to the difference in global score observed among controls approximately 10 years apart in age. Analyses of pack-years of smoking prior to disease onset gave similar results. These findings, nested in prospective cohort studies, suggest that cigarette smoking prior to disease onset is associated with worse cognitive function in PD. [Description provided by NIOSH]
• Subjects:
  Aging Education Epidemiology Men Nervous System Occupational Health Risk Assessment Risk Factors Safety Smokers Surveys And Questionnaires Women

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• Keywords:
  Age Groups Author Keywords: Parkinsons Disease Case Control Studies Cognitive Function Humans Neurophysiological Effects Neurophysiology Parkinsons Disease Prospective Studies Questionnaires Risk Factors Smoking

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• ISSN:
  1531-8257
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  5
• NIOSHTIC Number:
  nn:20059842
• Citation:
  Mov Disord 2007 Apr; 22(5):660-665
• Contact Point Address:
  Marc G. Weisskopf, Department of EnvironmentalHealth, Harvard School of Public Health, Landmark Center, 3rd floor East, PO Box 15697, Boston, MA 02215
• Email:
  mweissko@hsph.harvard.edu
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Movement Disorders
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:81660913c0456789068909c010d4a70fd2b20e650c05e12c3dcfc25cc7736eede0b3f66957ccd54ba1d7a98422848e634213c3035e0b427e02cbaca2f1da74af
• Download URL:
  https://stacks.cdc.gov/view/cdc/223908/cdc_223908_DS1.pdf
• File Type:
  [PDF - 95.94 KB ]