Asbestos Exposure, Manganese Superoxide Dismutase (MnSOD) Genotype, and Lung Cancer Risk

Details

• Personal Author:
  Christiani, David C. ; Neuberg D ; Wang LI
• Description:
  To assess whether differences in genetic susceptibility to oxidative stress modify asbestos-related lung cancer risk (caused by lung inflammation, free radical production), we examined possible interactions between manganese superoxide dismutase (MnSOD) genotypes and asbestos in a hospital-based case-control study of 811 white lung cancer cases and 957 friend/spouse controls. Cumulative lifetime asbestos exposure score (AES) was calculated from self-reported duration and intensity of occupational and nonoccupational exposures. A total of 13.5% of cases and 10% of controls had "high" AES (determined by a priori cut point). The homozygous variant MnSOD genotype was associated with increased lung cancer risk among individuals with zero or "low" AES (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.52-3.01) and no association (OR = 1.00; 95% CI = 0.36-2.73) among the "high" AES group. We observed no statistically significant interaction between MnSOD genotype and asbestos exposure for lung cancer risk. [Description provided by NIOSH]
• Subjects:
  Asbestos Environmental Exposure Inorganic Chemicals Lung Lung Diseases Manganese Men Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Women

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• Keywords:
  Cancer Case Control Studies Exposure Levels Genotype Humans Lung Cancer Oxidative Stress Risk Factors Statistical Analysis
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  46
• Issue:
  6
• NIOSHTIC Number:
  nn:20059682
• Citation:
  J Occup Environ Med 2004 Jun; 46(6):556-564
• Contact Point Address:
  David C. Christiani, MD, Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue, Bldg 1., Room 1402, Boston, MA 02115
• Email:
  dchris@hohp.harvard.edu
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2004
• Performing Organization:
  Harvard School of Public Health, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19980701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20030630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7d9522350113e20d9a18d9c3cceda5105afb27d7b0a7760366c52786de3f3b83dce5b92b670aba47a1082b93290dc14205ebe5eed9255fd773810d50692f6acf
• Download URL:
  https://stacks.cdc.gov/view/cdc/223829/cdc_223829_DS1.pdf
• File Type:
  [PDF - 203.51 KB ]