A Case Control Study of Lung Cancer and Exposure to Chrysotile and Amphibole at a Slovenian Asbestos-Cement Plant

Details

• Personal Author:
  Dodic-Fikfak M ; Eisen EA ; Kriebel D ; Quinn, Margaret M. ; Wegman, David H.
• Description:
  A lung cancer case-control study was conducted in a Slovenian asbestos-cement factory for which unusually good records of asbestos exposures were available. The cohort consisted of all 6714 workers employed at the Salonit Anhovo factory after 31 December 1946 who worked there for at least one day between 1964 and 1994. Fifty-eight histologically confirmed cases of primary lung cancer and 290 controls were selected from the cohort. Working life exposure histories to amphibole and chrysotile forms of asbestos were estimated separately. Airborne asbestos concentrations were low. For example, the arithmetic mean exposure to all forms of asbestos in the highest exposure period (1947-1971) was 1.2 f/cm(3). Chrysotile asbestos made up about 90% of this exposure (mean 1.1 f/cm(3)), whereas amphibole accounted for 10% (0.1 f/cm(3)). Comparing those above and below the 90 percentile of cumulative exposure, the odds ratios for all asbestos, chrysotile and amphibole were 1.5, 1.6 and 2.0, respectively, but confidence intervals were wide. There are only a few asbestos-lung cancer studies with high-quality exposure data and exposures in this low range. Though imprecise, the findings are important to the ongoing debate about asbestos risks. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Asbestos Carcinogens Environmental Exposure Epidemiology Hazardous Substances Inorganic Chemicals Lung Lung Diseases Manufacturing And Industrial Facilities Men Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Women Workplace

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• Keywords:
  Airborne Fibers Amphibole Theory Author Keywords: Amphiboles Cancer Case Control Studies Cements Chemical Industry Workers Chrysotile Exposure Levels Health Effects Humans Lung Cancer Risk Assessment Risk Factors Toxins Work Environment Workers

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• ISSN:
  0003-4878
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  261-268
• Volume:
  51
• Issue:
  3
• NIOSHTIC Number:
  nn:20055616
• Citation:
  Ann Occup Hyg 2007 Apr; 51(3):261-268
• Contact Point Address:
  M. Dodic Fikfak, Clinical Institute of Occupational Medicine, University Medical Centre, 1000 Ljubljana, Slovenia
• Email:
  metoda.dodic-fikfak@guest.arnes.si
• CAS Registry Number:
  Amphibole-group minerals (CAS RN 1318-09-8) ; Asbestos (CAS RN 1332-21-4) ; Chrysotile (CAS RN 12001-29-5)
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Annals of Occupational Hygiene
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6a4ee5eac2ea7e643ba7e2c07486e391c519bb3d0ca014543e817bc0b7d359fcb01834ca9932c2175dfb410de72346c4dd0e58b56d64c6ec04013e60d7ce87db
• Download URL:
  https://stacks.cdc.gov/view/cdc/213426/cdc_213426_DS1.pdf
• File Type:
  [PDF - 175.37 KB ]