Exposure to Environmental Tobacco Smoke and Urinary 1-Hydroxypyrene Levels in Preschool Children

Details

• Personal Author:
  Christiani, David C. ; Hauser R ; Ho C-K ; Liu C-L ; Rodrigues E ; Tsai H-T ; Wu M-T
• Description:
  Environmental tobacco smoke (ETS) contains relatively high concentrations of polycyclic aromatic hydrocarbons (PAHs). Urinary 1-hydroxypyrene (1-OHP), a metabolite of pyrene, is a good indicator of PAH exposure in occupational studies. In this study, we investigated the relationship between urinary 1-OHP concentration and ETS exposure in preschool children. Forty preschool children, aged 24-76 months, were studied during November and December, 1999. Two spot-urine specimens (one in the morning immediately after the subject woke up and the other at night before the subject went to bed) were collected 1 day after completion of a questionnaire, in order to determine 1-OHP concentrations by fluorescent spectrophotometry. Overall, urinary 1-OHP concentrations were relatively low but detectable (morning: median, 0.021 microg/g creatinine; range, 0.002-1.019 microg/g creatinine; night: median, 0.015 microg/g creatinine; range, 0.002-1.328 microg/g creatinine). Multiple linear regression analyses revealed that the total number of cigarettes smoked by the children's fathers during the 3 days prior to collection of the urine specimens was significantly associated with their urinary 1-OHP concentrations, after adjusting for other confounders. Each cigarette smoked by a child's father resulted in an average 9.6% increase in 1-OHP concentration in the morning urine specimen (95% confidence interval = 1.8-18.1%; p = 0.02). We did not find a significant increase in the 1-OHP concentration in night urine specimens (p = 0.19). Although the sample size was small, these findings indicate that urinary 1-OHP may be a suitable biomarker of ETS carcinogen exposure in children. [Description provided by NIOSH]
• Subjects:
  Aging Biomarkers Carcinogens Energy Metabolism Environmental Exposure Hydrocarbons Occupational Health Polycyclic Aromatic Hydrocarbons Risk Assessment Risk Factors Safety Smoke Tobacco Products

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• Keywords:
  Age Groups Author Keywords: Environmental Tobacco Smoke Children Environmental Exposure Exposure Levels Humans Metabolites PAH Polycyclic Aromatic Hydrocarbons Polynuclear Aromatic Hydrocarbons Preschool Children Pyrene Risk Factors Tobacco Smoke Urinary 1-hydroxypyrene

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• ISSN:
  1607-551X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  97-103
• Volume:
  19
• Issue:
  3
• NIOSHTIC Number:
  nn:20059636
• Citation:
  Kaohsiung J Med Sci 2003 Mar; 19(3):97-103
• Contact Point Address:
  Dr. MingTsang Wu, Graduate Institute of Occupational Safety and Health, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 807, Taiwan
• Email:
  mingtsangwu@yahoo.com
• CAS Registry Number:
  Pyrene (CAS RN 129-00-0)
• Federal Fiscal Year:
  2003
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20030701
• Source Full Name:
  The Kaohsiung Journal of Medical Sciences
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ae9a6f4b13fbe2e032964eb6c98e3ef12187513574f9c6105ec79dcc4ea1f0e0c0ab18087b79c0768b4127133a7822dd8fffcf0de7c1bd8f04545cb00e71f181
• Download URL:
  https://stacks.cdc.gov/view/cdc/223790/cdc_223790_DS1.pdf
• File Type:
  [PDF - 117.08 KB ]