Kidney Injury Biomarkers with Clinical Utility: Has Godot Finally Arrived?

Details

• Personal Author:
  Coca SG
• Description:
  Where does this leave us? Maybe we do not have the ideal urine biomarker ready to employ in the outpatient setting yet, "but surely tomorrow", as Vladimir and Estragon state at the end of Waiting for Godot. We will see what enlightenment we get regarding the performance and potential clinical utility of not only alpha-1 microglobulin but also other urinary biomarkers such as urinary EGF, MCP-1, KIM-1, and YKL-40, along with several plasma biomarkers assayed in multiple large cohorts, as part of work that will soon emerge from the CKD Biomarker Consortium (https://www.ckdbiomarkersconsortium.org/). This work will not merely have to demonstrate an "independent association" of any given biomarker or biomarkers with the kidney progression outcomes, but will have to also demonstrate some sort of clinical utility potential, in the form of strong positive or negative predictive value, before full consideration for clinical use can be justifiably entertained. Until those hurdles are crossed, I will continue to wait with Vladamir and Estragon for Godot (i.e., the urine biomarker[s] that reliably satisfies these characteristics). [Description provided by NIOSH]
• Subjects:
  Biomarkers Diagnosis Occupational Health Safety
• Keywords:
  Biological Monitoring Clinical Tests Diagnostic Techniques Kidney Disorders Nephrological Disorders
• ISSN:
  0250-8095
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  357-360
• Volume:
  50
• Issue:
  5
• NIOSHTIC Number:
  nn:20059330
• Citation:
  Am J Nephrol 2019 Nov; 50(5):357-360
• Contact Point Address:
  Steven G. Coca, DO, MS, Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, Box 1243, New York, NY 10029
• Email:
  Steven.Coca@mssm.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  False
• Start Date:
  20170701
• Source Full Name:
  American Journal of Nephrology
• End Date:
  20200630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6d83e3d8df843c2689a0e7d67162687b3f3bdc130513f4154afbea9b951ccd7f8706707e000ec6ea6801b1973f5f361761ae31405656d5e121373cd412b5c407
• Download URL:
  https://stacks.cdc.gov/view/cdc/223595/cdc_223595_DS1.pdf
• File Type:
  [PDF - 104.00 KB ]