Relationship of Bone and Blood Lead Levels to Psychiatric Symptoms: The Normative Aging Study

Details

• Personal Author:
  Aro A ; Hu H ; Rhodes, Daniel W. ; Spiro A III
• Description:
  Blood and bone lead levels were used to investigate lead's potential effect on psychiatric symptoms among middle-aged to elderly men from the Normative Aging Study. Symptoms were assessed using the Brief Symptom Inventory (BSI) and analyzed as individual outcomes as well as a measure that combined anxiety, depression, and phobic anxiety. Blood and bone lead averaged 6.3 microg/dL (standard deviation [SD] = 4.16), 21.9 microg/g (SD = 13.5), and 32.1 microg/g (SD = 19.8) for blood, tibia, and patella lead, respectively. In logistic regression models that adjusted for age, alcohol intake, employment status, and education status, we found that patella bone lead was significantly associated with an increased risk of phobic anxiety and the combined outcome measure at the P ≤0.05 level. Tibia and blood lead had similar associations. We conclude that cumulative lead exposure, which bone lead levels reflect, could be a risk factor for psychiatric symptoms even at modest levels of exposure. [Description provided by NIOSH]
• Subjects:
  Aging Education Lead Men Mental Health Nervous System Occupational Health Safety
• Keywords:
  Age Groups Alcohols Blood Lead Levels Bone Disorders Bone Structure Health Effects Humans Mental Health Mental Processes Models Psychological Effects

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  45
• Issue:
  11
• NIOSHTIC Number:
  nn:20059326
• Citation:
  J Occup Environ Med 2003 Nov; 45(11):1144-1151
• Contact Point Address:
  Dan Rhodes, MD, 255 Broadway, #2, Cambridge, MA 02139
• Email:
  DanRho@aol.com
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2004
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20030701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:514afac40a38991cb63dbafd54b4bca3cd3278490e9d067c02e9a345536dcc49bfd395223753b16b5ea094a8065cca93f165bb511ce343206fce7ee521f1d2c8
• Download URL:
  https://stacks.cdc.gov/view/cdc/223592/cdc_223592_DS1.pdf
• File Type:
  [PDF - 127.03 KB ]