Associations of Cumulative Pb Exposure and Longitudinal Changes in Mini-Mental Status Exam Scores, Global Cognition and Domains of Cognition: The VA Normative Aging Study

Details

• Personal Author:
  Bakulski KM ; Farooqui Z ; Hu H ; Nie LH ; Park SK ; Power MC ; Sparrow D ; Spiro A III ; Vokonas PS ; Weisskopf MG
• Description:
  Background: Lead (Pb) exposure has been associated with poorer cognitive function cross-sectionally in aging adults, however the association between cumulative Pb exposure and longitudinal changes in cognition is little characterized. Methods: In a 1993-2007 subcohort of the VA Normative Aging Study (Mini-mental status exam (MMSE) n=741; global cognition summary score n=715), we used linear mixed effects models to test associations between cumulative Pb exposure (patella or tibia bone Pb) and repeated measures of cognition (MMSE, individual cognitive tests, and global cognition summary). Cox proportional hazard modeling assessed the risk of an MMSE score falling below 25. Results: Among men 51-98 at baseline, higher patella Pb concentration (IQR: 21 microg/g) was associated with -0.13 lower baseline MMSE (95% CI: -0.25, -0.004) and faster longitudinal MMSE decline (-0.016 units/year, 95% CI: -0.032, -0.0004) over 15 years. Each IQR increase in patella Pb was associated with increased risk of a MMSE score below 25 (HR=1.21, 95% CI: 0.99, 1.49; p=0.07). There were no significant associations between Pb and global cognition (both baseline and longitudinal change). Patella Pb was associated with faster longitudinal decline in Word List Total Recall in the language domain (0.014 units/year, 95% CI: -0.026, -0.001) and Word List Delayed Recall in the memory domain (0.014 units/year, 95% CI: -0.027, -0.002). We found weaker associations with tibia Pb. Conclusions: Cumulative Pb exposure is associated with faster declines in MMSE and Word List Total and Delayed Recall tests. These findings support the hypothesis that Pb exposure accelerates cognitive aging. [Description provided by NIOSH]
• Subjects:
  Aging Lead Men Mental Disorders Mental Health Nervous System Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Author Keywords: Cognitive Decline Bone Lead Bone Structure Cognitive Function Exposure Assessment Humans Intellectual Disabilities Lead Absorption Lead Compounds Longitudinal Study Mental Disorders Mental Processes MMSE Psychological Testing Risk Assessment Risk Factors

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; Indiana ; Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  102-108
• Volume:
  152
• NIOSHTIC Number:
  nn:20049726
• Citation:
  Environ Res 2017 Jan; 152:102-108
• Contact Point Address:
  Sung Kyun Park, Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
• Email:
  sungkyun@umich.edu
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6159756102b3a654afc2811ee4ef242069db9b5ccc4ea0d20821b5598fb13dc40f1d6300b2b72d1d8784b1c596c1c8405ed876549b618aef75233f298a4259c6
• Download URL:
  https://stacks.cdc.gov/view/cdc/210368/cdc_210368_DS1.pdf
• File Type:
  [PDF - 245.23 KB ]