Impact of Dietary Exposure to Food Contaminants on the Risk of Parkinson’s Disease

Details

• Personal Author:
  Bech S ; Budtz-Jorgensen E ; Grandjean P ; Hallig J ; Jorgensen PJ ; Nielsen F ; Petersen MS ; Weihe P ; Wermuth L
• Description:
  This study aimed to investigate the association of Parkinson's disease (PD) with dietary exposure to polychlorinated biphenyls (PCBs) and methylmercury (MeHg) in a community with increased exposure levels. A total of 79 clinically verified idiopathic PD cases and 154 controls matched by sex and age were examined in this case-control study in the Faroe Islands. Blood and hair samples were collected and a questionnaire recorded lifetime information on residence, dietary habits, smoking history, and occupational exposure to solvents, pesticides, and metals. Both unconditional and conditional logistic regression analyses were used to estimate the odds ratio (OR) and 95% confidence interval (CI) in regard to relevant exposure variables. Increased ORs for dietary intakes of whale meat and blubber during adult life were statistically significant. The ORs for occupational exposure to solvents, pesticides and metals also suggested an increased risk for PD. Current serum concentrations of summation operator PCB and related contaminants suggested slightly increased ORs, although only beta-hexachlorocyclohexane (beta-HCH) was statistically significant. Increased intake of whale meat and blubber in adult life was significantly associated with PD, thus suggesting a positive association between previous exposure to marine food contaminants and development of PD. [Description provided by NIOSH]
• Subjects:
  Aging Blood Diet Environmental Exposure Hematologic Tests Men Occupational Health Polychlorinated Biphenyls Safety Surveys And Questionnaires Women

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• Keywords:
  Age Groups Author Keywords: Diet Blood Samples Case Control Studies Environmental Exposure Etiology Faroe Islands Food Contaminants Hair Analysis Methylmercury Compounds Parkinsonism Parkinsons Disease PCBs Polychlorinated Biphenyls Questionnaires Statistical Analysis

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• ISSN:
  0161-813X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  29
• Issue:
  4
• NIOSHTIC Number:
  nn:20059204
• Citation:
  Neurotoxicology 2008 Jul; 29(4):584-590
• Contact Point Address:
  Maria Skaalum Petersen, Institute of Public Health, Environmental Medicine, University of Southern Denmark, Winslowparken 17, 5000 Odense C, Denmark
• Email:
  mskaalum@health.sdu.dk
• CAS Registry Number:
  1,1′-Biphenyl, chloro derivs. (CAS RN 1336-36-3) ; Methylmercury(1+) (CAS RN 22967-92-6)
• Federal Fiscal Year:
  2008
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Neurotoxicology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4eedd84b933369c4a0aa8416df4349be3bff360618e5a3b5492ac482c939fcf2570e04ebe938b7ff68323fd53938262d2cb100bbae8644d1e518222466d9c09b
• Download URL:
  https://stacks.cdc.gov/view/cdc/223494/cdc_223494_DS1.pdf
• File Type:
  [PDF - 168.33 KB ]