Effects of Environmental and Occupational Pesticide Exposure on Human Sperm: A Systematic Review

Details

• Personal Author:
  Perry MJ
• Description:
  Relatively recent discoveries of the hormone disrupting properties of some pesticides have raised interest in how contemporary pesticide exposures, which primarily take the form of low level environmental or occupational exposures, impact spermatogenesis. The objective of the present review was to summarize results to date of studies examining pesticide effects on human sperm. Outcomes evaluated included sperm parameters, DNA damage and numerical chromosome aberrations (aneuploidy (disomy, nullisomy) or diploidy). Studies investigating sperm in men environmentally and/or occupationally exposed to any types of pesticides were included in the review. The targeted literature search over the last 15 years showed a range of pesticide classes have been investigated including pyrethroids, organophosphates, phenoxyacetic acids, carbamates, organochlorines and pesticide mixtures. None of the studies involved acute exposure events such as chemical accidents. There were 20 studies evaluating semen quality, of which 13 studies reported an association between exposure and semen quality; 6 studies evaluating DNA damage, of which 3 reported an association with exposure; and 6 studies assessing sperm aneuploidy or diploidy, of which 4 reported an association with exposure. Studies varied widely in methods, exposures and outcomes. Although suggestive for semen parameters, the epidemiologic evidence accumulated thus far remains equivocal as to the spermatotoxic and aneugenic potential of pesticides given the small number of published studies. This question warrants more investigation and suggestions for future studies are outlined. [Description provided by NIOSH]
• Subjects:
  Carbamates Chromosomes Endocrine System Environmental Exposure Environmental Pollution Hazardous Substances Insecticides Men Occupational Health Risk Assessment Risk Factors Safety Spermatogenesis Urogenital Diseases Urogenital System

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• Keywords:
  Author Keywords: Semen Quality Chromosome Damage Chromosomes Deoxyribonucleic Acids DNA DNA Damage Environmental Exposure Environmental Hazards Environmental Health Exposure Levels Health Effects Health Hazards Hormones Humans Occupational Health Organochlorine Compounds Organophosphorus Compounds Pesticides Physiological Effects Pyrethroids Reproductive Effects Reproductive Hazards Reproductive Health Reproductive System Disorders Risk Factors

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• ISSN:
  1355-4786
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  233-242
• Volume:
  14
• Issue:
  3
• NIOSHTIC Number:
  nn:20059187
• Citation:
  Hum Reprod Update 2008 May/Jun; 14(3):233-242
• Contact Point Address:
  Melissa J. Perry, Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115
• Email:
  lmperry@hsph.harvard.edu
• Federal Fiscal Year:
  2008
• Performing Organization:
  Harvard School of Public Health, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19980701
• Source Full Name:
  Human Reproduction Update
• End Date:
  20030630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5a7614c1d553215c839818b67dc27864192697badca7cf6271e2def8443dc7160bca887b9775ca92ab868eaa87cc395df39115785c23fbad517d11595b6b6464
• Download URL:
  https://stacks.cdc.gov/view/cdc/223481/cdc_223481_DS1.pdf
• File Type:
  [PDF - 152.10 KB ]