Predictors of Urinary and Blood Metal(loid) Concentrations Among Pregnant Women in Northern Puerto Rico

Details

• Personal Author:
  Alshawabkeh A ; Ashrap P ; Boss J ; Cordero JF ; Meeker JD ; Mukherjee B ; Richards MJ ; Rosario Z ; Velez-Vega CM ; Watkins DJ
• Description:
  Given the potential adverse health effects related to toxic trace metal exposure and insufficient or excessive levels of essential trace metals in pregnant women and their fetuses, the present study characterizes biomarkers of metal and metalloid exposure at repeated time points during pregnancy among women in Puerto Rico. We recruited 1040 pregnant women from prenatal clinics and collected urine, blood, and questionnaire data on demographics, product use, food consumption, and water usage at up to three visits. All samples were analyzed for 16 metal(loid)s: arsenic (As), barium (Ba), beryllium (Be), cadmium (Cd), cobalt (Co), chromium (Cr), cesium (Cs), copper (Cu), mercury (Hg), manganese (Mn), nickel (Ni), lead (Pb), titanium (Ti), uranium (U), vanadium (V), and zinc (Zn). Urine samples were additionally analyzed for molybdenum (Mo), platinum (Pt), antimony (Sb), tin (Sn), and tungsten (W). Mean concentrations of most metal(loid)s were higher among participants compared to the general US female population. We found weak to moderate correlations for inter-matrix comparisons, and moderate to strong correlations between several metal(loid)s measured within each biological matrix. Blood concentrations of Cu, Zn, Mn, Hg, and Pb were shown to reflect reliable biomarkers of exposure. For other metals, repeated samples are recommended for exposure assessment in epidemiology studies. Predictors of metal(loid) biomarkers included fish and rice consumption (urinary As), fish and canned food (blood Hg), drinking public water (blood Pb), smoking (blood Cd), and iron/folic acid supplement use (urinary Cs, Mo, and Sb). Characterization of metal(loid) biomarker variation over time and between matrices, and identification of important exposure sources, may inform future epidemiology studies and exposure reduction strategies. Description provided by NIOSH
• Subjects:
  • Antimony
  • Arsenic
  • Biomarkers
  • Blood
  • Cadmium
  • Chromium
  • Copper
  • Demography
  • Environmental Exposure
  • Epidemiology
  More +
• Keywords:
  • Urine
  • Urine chemistry
  • Metal compounds
  • Humans
  • Women
  • Racial factors
  • Pregnancy
  • Exposure levels
  • Risk factors
  • Health effects
  More +
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5 ; Puerto Rico
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  183
• NIOSHTIC Number:
  nn:20058799
• Citation:
  Environ Res 2020 Apr; 183:109178
• Contact Point Address:
  John D. Meeker, University of Michigan School of Public Health, Department of Environmental Health Sciences, 1415 Washington Heights, Ann Arbor, MI, 48109
• Email:
  meekerj@umich.edu
• CAS Registry Number:
  • Antimony (CAS RN 7440-36-0)
  • Arsenic (CAS RN 7440-38-2)
  • Barium (CAS RN 7440-39-3)
  • Beryllium (CAS RN 7440-41-7)
  • Cadmium (CAS RN 7440-43-9)
  • Cesium (CAS RN 7440-46-2)
  • Chromium (CAS RN 7440-47-3)
  • Cobalt (CAS RN 7440-48-4)
  • Copper (CAS RN 7440-50-8)
  • Lead (CAS RN 7439-92-1)
  More +
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20280630
• Download URL:
  https://stacks.cdc.gov/view/cdc/223195/cdc_223195_DS1.pdf
• File Type:
  [PDF - 1.22 MB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7934b5ac7f0fa96f716fe4bbdd2a3203b6df7a90c0a3e4378ba44cd65325433fd699734363ac62f4cd56c225572ca7d9d7abe54ad4a1358f2d3ddea5f8ece972