Smoking and the Risk of Lung Cancer: Susceptibility with GSTP1 Polymorphisms

Details

• Personal Author:
  Christiani, David C. ; De Vivo I ; Lynch TJ ; Miller DP ; Neuberg D ; Su L ; Wain JC ; Christiani, David C. ; De Vivo I ; Lynch TJ ; Miller DP ; Neuberg D ; Su L ; Wain JC
• Description:
  BACKGROUND: GSTP1 is a gene that helps detoxify foreign substances in the body. Functional polymorphisms of GSTP1 have been studied as risk factors for lung cancer. Past studies have compared the effect of the 'at risk' polymorphism in two strata of smoking pack-years (usually defined by the median among controls). We examined the interaction between GSTP1 polymorphisms and cumulative exposure to smoking and their association with lung cancer risk. METHODS: Data are from a large hospital-based case-control study of persons treated for primary lung cancer at the Massachusetts General Hospital since 1992. Controls were drawn from friends and nonrelated family members. We genotyped 1,042 cases and 1,161 controls for GSTP1 using polymerase chain reaction-restriction fragment length polymorphism techniques. FINDINGS: The GSTP1 GG genotype approximately doubled the lung cancer risk associated with pack-years. This interaction was stronger among current smokers. At 26 pack-years (median among controls with a smoking history), the adjusted odds ratio for the association between pack-years and lung cancer risk was 13 (95% confidence interval = 6.5-25) among current smokers with the GSTP1 GG genotype compared with 6.1 (95% confidence interval = 4.9-7.5) among those with the GSTP1 AA genotype. CONCLUSIONS: GSTP1 GG increases the lung cancer risk associated with pack-years of smoking. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Genetics Lung Lung Diseases Men Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smokers Women

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• Keywords:
  Author Keywords: GSTP1 Cancer Case-control Detoxifying Agents Exposure Levels Genes Humans Lung Cancer Risk Factors Smoking Susceptibility

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• ISSN:
  1044-3983
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  14
• Issue:
  5
• NIOSHTIC Number:
  nn:20058707
• Citation:
  Epidemiology 2003 Sep; 14(5):545-551
• Contact Point Address:
  David C. Christiani, Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue Bldg 1 Room 1402, Boston, MA 02115
• Email:
  dchris@hohp.harvard.edu
• Federal Fiscal Year:
  2003
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20030701
• Source Full Name:
  Epidemiology
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c9b7f428b3a6e301aea928769af1cf178336e2cd503ba25073bfe27d147a46d0ff0263d0135b5d1c38c34032c07f7bf3c200e58b8dc1f6a5e16b0b9748054cba
• Download URL:
  https://stacks.cdc.gov/view/cdc/223108/cdc_223108_DS1.pdf
• File Type:
  [PDF - 424.91 KB ]