Effects of the 2018 Camp Fire on Birth Outcomes in Non-Human Primates: Case-Control Study

Details

• Personal Author:
  Gee NA ; Lasley BL ; Li L ; Pinkerton KE ; Willits NH ; Willson BE ; Zhang Q
• Description:
  The November 2018 Camp Fire, a devastating wildfire in Northern California, occurred during the peak of breeding season for field monkeys at the California National Primate Research Center (CNPRC). Effects of environmental stressors, such as wildfires, on birth outcomes in primates, and in humans, are poorly understood. Additionally, wildfires are of growing concern due to their increasing frequency and severity. The objective was to examine the impact of wildfire smoke on fertility, timing of birth, and pregnancy loss for field monkeys. A unique case-control study to investigate birth outcomes in rhesus macaques (Macaca mulatta) was conducted at the CNPRC. All females in the study were maintained in outdoor fields during a period of elevated ambient wildfire smoke from November 8-22, 2018. In addition to ambient air quality evaluations, the effects on fertility, timing to birth, and pregnancy loss were documented. Archival records of approximately 5,000 conceptions from the previous nine years served as control data. During the Camp Fire, ambient fine particulate (PM 2.5) levels exceeded the 24 -h National Ambient Air Quality Standard (35 µg/m 3) of the United States Environmental Protection Agency, reaching levels as high as 185 µg/m 3. A statistically significant association was observed between birth loss and the 2018-2019 CNPRC breeding season. As this wildfire event occurred during various stages of early pregnancy, an association can be inferred between early gestational exposure and increased risk of pregnancy loss. [Description provided by NIOSH]
• Subjects:
  Air Pollution Air Pollution, Indoor Animals Environmental Exposure Fires Occupational Health Pregnancy Safety Wildfires
• Keywords:
  Author Keywords: Air-quality Case Control Studies Climate Environmental Exposure Miscarriage Particulate Phthalate Prenatal Exposure Primate Smoke Smoke Inhalation Wildfire

  More +
• ISSN:
  0890-6238
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  128-135
• Volume:
  105
• NIOSHTIC Number:
  nn:20064688
• Citation:
  Reprod Toxicol 2021 Oct; 105:128-135
• Contact Point Address:
  Bryn E. Willson, Department of Obstetrics and Gynecology, UC Davis Health, 4860 Y street, Suite 2500. Sacramento, CA 95817
• Email:
  bryn.willson@cshs.org
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Reproductive Toxicology
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:813eb3ce67f7fffc199701cd1591e16a4543c8833f53827cf29901d765ede3ea28de7ba112d2fa1f52385be3669a648e2cd60c8b58c242a8f9c192137d666dc3
• Download URL:
  https://stacks.cdc.gov/view/cdc/223097/cdc_223097_DS1.pdf
• File Type:
  [PDF - 2.58 MB ]