Factors Associated with Shorter Colonoscopy Surveillance Intervals for Patients with Low-Risk Colorectal Adenomas and Effects on Outcome

Details

• Personal Author:
  Ahnen DJ ; Anderson JC ; Baron JA ; Barry EL ; Bostick RM ; Bresalier RS ; Burke CA ; Church, Timothy R. ; Cole BF ; Cruz-Correa M ; Kim AS ; Mott LA ; Robertson DJ ; Sandler RS
• Description:
  Background & Aims: Endoscopists do not routinely follow guidelines to survey individuals with low-risk adenomas (LRAs; 1-2 small tubular adenomas, < 1 cm) every 5-10 years for colorectal cancer; many recommend shorter surveillance intervals for these individuals. We aimed to identify the reasons that endoscopists recommend shorter surveillance intervals for some individuals with LRAs and determine whether timing affects outcomes at follow-up examinations. Methods: We collected data from 1560 individuals (45-75 years old) who participated in a prospective chemoprevention trial (of vitamin D and calcium) from 2004 through 2008. Participants in the trial had at least 1 adenoma, detected at their index colonoscopy, and were recommended to receive follow-up colonoscopy examinations at 3 or 5 years after adenoma identification, as recommended by the endoscopist. For this analysis we collected data from only participants with LRAs. These data included characteristics of participants and endoscopists and findings from index and follow-up colonoscopies. Primary endpoints were frequency of recommending shorter (3-year) vs longer (5-year) surveillance intervals, factors associated with these recommendations, and effect on outcome, determined at the follow-up colonoscopy. Results: A 3-year surveillance interval was recommended for 594 of the subjects (38.1%). Factors most significantly associated with recommendation of 3-year vs a 5-year surveillance interval included African American race (relative risk [RR] to white, 1.41; 95% confidence interval [CI], 1.14-1.75), Asian/Pacific Islander ethnicity (RR to white, 1.7; 95% CI, 1.22-2.43), detection of 2 adenomas at the index examination (RR vs 1 adenoma, 1.47; 95% CI, 1.27-1.71), more than 3 serrated polyps at the index examination (RR=2.16, 95% CI, 1.59-2.93), or index examination with fair or poor quality bowel preparation (RR vs excellent quality, 2.16; 95% CI, 1.66-2.83). Other factors that had a significant association with recommendation for a 3-year surveillance interval included family history of colorectal cancer and detection of 1-2 serrated polyps at the index examination. In comparisons of outcomes, we found no significant differences between the 3-year vs 5-year recommendation groups in proportions of subjects found to have 1 or more adenomas (38.8% vs 41.7% respectively; P = .27), advanced adenomas (7.7% vs 8.2%; P = .73) or clinically significant serrated polyps (10.0% vs 10.3%; P = .82) at the follow-up colonoscopy. Conclusions: Possibly influenced by patients' family history, race, quality of bowel preparation, or number or size of polyps, endoscopists frequently recommend 3-year surveillance intervals instead of guideline-recommended intervals of 5 years or longer for individuals with LRAs. However, at the follow-up colonoscopy, similar proportions of participants have 1 or more adenomas, advanced adenomas, or serrated polyps. These findings support the current guideline recommendations of performing follow-up examinations of individuals with LRAs at least 5 years after the index colonoscopy. [Description provided by NIOSH]
• Subjects:
  Health Care Facilities Workforce And Services Neoplasms Occupational Health Safety
• Keywords:
  Author Keywords: Colon Cancer Cancer Rates Colorectal Cancer Detection Medical Management Guidelines Medical Monitoring Medical Screening Progression Surveillance Tumor Development
• ISSN:
  0016-5085
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Georgia ; Minnesota ; New Hampshire ; North Carolina ; Ohio ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 8 ; Puerto Rico ; Vermont
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  152
• Issue:
  8
• NIOSHTIC Number:
  nn:20064535
• Citation:
  Gastroenterology 2017 Jun; 152(8):1933-1943.e5
• Contact Point Address:
  Joseph C. Anderson, MD, VA Medical Center, 215 North Main Street, White River Junction, Vermont 05009
• Email:
  joseph.anderson@dartmouth.edu
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Minnesota Twin Cities
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Gastroenterology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b480323e0118b893ebcb7de65657f911b55267a532f2a35cb214ac771b3b1d1861c03b53264e9211980b09bd342a571616dbfd3297f59794087ed295f2a8ace1
• Download URL:
  https://stacks.cdc.gov/view/cdc/222980/cdc_222980_DS1.pdf
• File Type:
  [PDF - 842.32 KB ]