High-Fat Western Diet Consumption Exacerbates Silica-Induced Pulmonary Inflammation and Fibrosis (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Adipose tissue (AT), an endocrine organ, plays a central role in maintenance of whole-body energy homeostasis through its release of adipokines. Obesity, affecting over 40% of American adults, disrupts adipocyte metabolism leading to chronic systemic inflammation and metabolic dysfunction (MetDys). MetDys is associated with impaired lung function, pulmonary hypertension, and asthma. The aim of this study was to investigate the effects of high-fat Western diet (HFWD)-consumption on silica-induced pulmonary inflammation and fibrosis in the F344 rat. [Description provided by NIOSH]
• Subjects:
  Animals Body Weight Diet Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide
• Keywords:
  Adipose Tissue Animal Studies Body Weight Dietary Effects Lung Fibrosis Lung Function Metabolic Disorders Obesity Pulmonary System Silica
• DOI:
  https://doi.org/10.26616/NIOSHRD-1032-2022-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20064523
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1032-2022-0, 2022 May; :dataset
• Contact Point Address:
  Pathology and Physiology Research Branch (PPRB), Health Effects Lab Division (HELD), National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV. Phone: 304.285.5831
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  2022
• NORA Priority Area:
  Construction ; Mining
• Peer Reviewed:
  False
• Source Full Name:
  High-fat Western diet consumption exacerbates silica-induced pulmonary inflammation and fibrosis
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:54ce4c9c4dedc56773e39664082ace8b93a438d9e6444d790378de7eb5d59d9572bb3d582a4419b86744b71a4d117445c6d04b97ee6b2a6ea98c5eee686a1d7f
• Download URL:
  https://stacks.cdc.gov/view/cdc/222970/cdc_222970_DS1.pdf
• File Type:
  [PDF - 755.31 KB ]