High-Fat Western Diet-Consumption Alters Crystalline Silica-Induced Serum Adipokines, Inflammatory Cytokines and Arterial Blood Flow in the F344 Rat

Details

• Personal Author:
  Fedan, Jeffery S. ; Johnston RA ; Kashon ML ; Krajnak, Kristine M. ; McKinney W ; Thompson JA
• Description:
  Adipose tissue (AT) plays a central role in the maintenance of whole-body energy homeostasis through release of adipokines. High-fat Western diet (HFWD)-consumption contributes to obesity, disruption of adipocyte metabolism, chronic systemic inflammation, and metabolic dysfunction (MetDys). MetDys is associated with impaired lung function, pulmonary hypertension, and asthma. Thirty-five percent of adults in the U.S. have MetDys, yet the impact of MetDys on susceptibility to occupational hazards is unknown. The aim of this study was to determine the potential of HFWD-consumption to alter inhaled crystalline silica dust-induced metabolic responses. Six-wk old male F344 rats were fed a HFWD (45 kcal % fat, sucrose 22.2 % by weight) or standard rat chow (STD, controls), and exposed to silica-inhalation (6 h/d, 5 d/wk, 39 d; Min-U-Sil 5(R), 15 mg/m3) or filtered air. Indices of MetDys and systemic inflammation were measured at 0, 4, and 8 wk following cessation of silica exposure. At 8 wk post-exposure, silica reduced serum leptin and adiponectin levels, and increased arterial pulse frequency. HFWD-consumption induced weight gain, altered adipokines, liver, kidney, and pancreatic function, and increased tail artery blood flow. At 8 wk in HFWD + SIL-treated animals, the levels of serum pro-inflammatory cytokines (IFN-gamma, CXCL-1, TNF-alpha, IL-1beta, IL-4, IL-5, IL-6, IL-10 and IL-13) were increased compared to STD + SIL but were less than HFWD + AIR-induced levels. In conclusion, consumption of a HFWD altered silica-induced metabolic responses and silica exposure disrupted AT endocrine function. These findings demonstrate previously unknown interactions between HFWD-consumption and occupational silica exposure. [Description provided by NIOSH]
• Subjects:
  Animals Body Weight Diet Immune System Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide

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• Keywords:
  Adipokines Adipose Tissue Animal Studies Author Keywords: Obesity Body Weight Chronic Inflammation Crystalline Silica Cytokines Immune Reaction Inflammation Lung Fibrosis Metabolic Disorders Obesity Pulmonary System Silicosis

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• ISSN:
  2214-7500
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  12-21
• Volume:
  9
• NIOSHTIC Number:
  nn:20064251
• Citation:
  Toxicol Rep 2022 Jan; 9:12-21
• Contact Point Address:
  Janet A. Thompson, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1000 Frederick Lane, Morgantown, WV 26508, United States
• Email:
  jsd7@cdc.gov
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  2022
• NORA Priority Area:
  Construction ; Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology Reports
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a30b9e3ee5dc7b796984a71f9dc5313304881630562277c1f86e1001549bee913c911355bff3e290e63b221d68014cc23836535e80a457973d38beffb6f2ec52
• Download URL:
  https://stacks.cdc.gov/view/cdc/222750/cdc_222750_DS1.pdf
• File Type:
  [PDF - 2.94 MB ]