Risk Factors for Healthcare Personnel Infection with Endemic Coronaviruses (HKU1, OC43, NL63, 229E): Results from the Respiratory Protection Effectiveness Clinical Trial (ResPECT)

Details

• Personal Author:
  Bessesen MT ; Brown AC ; Cummings DAT ; Gaydos CA ; Gibert CL ; Gorse GJ ; Hitchings MDT ; Lessler J ; Nyquist A-C ; Perl TM ; Price CS ; Radonovich LJ Jr. ; Rattigan SM ; Reich NG ; Rodriguez-Barradas MC ; Simberkoff MS
• Description:
  BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a large risk to healthcare personnel (HCP). Quantifying the risk of coronavirus infection associated with workplace activities is an urgent need. METHODS: We assessed the association of worker characteristics, occupational roles and behaviors, and participation in procedures with the risk of endemic coronavirus infection among HCP who participated in the Respiratory Protection Effectiveness Clinical Trial (ResPECT), a cluster randomized trial to assess personal protective equipment to prevent respiratory infections and illness conducted from 2011 to 2016. RESULTS: Among 4689 HCP seasons, we detected coronavirus infection in 387 (8%). HCP who participated in an aerosol-generating procedure (AGP) at least once during the viral respiratory season were 105% (95% confidence interval, 21%-240%) more likely to be diagnosed with a laboratory-confirmed coronavirus infection. Younger individuals, those who saw pediatric patients, and those with household members <5 years of age were at increased risk of coronavirus infection. CONCLUSIONS: Our analysis suggests that the risk of HCP becoming infected with an endemic coronavirus increases approximately 2-fold with exposures to AGPs. Our findings may be relevant to the coronavirus disease 2019 (COVID-19) pandemic; however, SARS-CoV-2, the virus that causes COVID-19, may differ from endemic coronaviruses in important ways. CLINICAL TRIALS REGISTRATION: NCT01249625. [Description provided by NIOSH]
• Subjects:
  Aerosols Behavior Communicable Diseases Environmental Exposure Health Personnel Occupational Health Personal Protective Equipment Respiratory Protective Devices Respiratory Tract Diseases Risk Assessment Risk Factors Safety Viral Diseases Workplace

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• Keywords:
  Aerosol Generating Procedure Author Keywords: 229E Coronavirus Exposure Levels Health Care Personnel Health Care Workers HKU1 Infectious Agents NL63 OC43 Personal Protective Equipment PPE Respiratory Protection Respiratory System Disorders Risk Factors Statistical Analysis Viral Infections Work Environment Workers

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• ISSN:
  1058-4838
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; District of Columbia ; Florida ; Maryland ; Massachusetts ; Missouri ; New York ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 6 ; OSHA Region 7 ; OSHA Region 8 ; Texas ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  73
• Issue:
  11
• NIOSHTIC Number:
  nn:20064374
• Citation:
  Clin Infect Dis 2021 Dec; 73(11):e4428-e4432
• Contact Point Address:
  D. A. T. Cummings, Department of Biology, University of Florida, Gainesville, FL 32608
• Email:
  datc@ufl.edu
• Federal Fiscal Year:
  2022
• Peer Reviewed:
  True
• Source Full Name:
  Clinical Infectious Diseases
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2769e8c7e0cd4f48ae59c7ef54e79cc05b9fac5acbb6f9e2f0ee5d1d77fa631256d42d34a1534dee697fb122c2f224a3572d283652115721d735ac426536ac39
• Download URL:
  https://stacks.cdc.gov/view/cdc/222849/cdc_222849_DS1.pdf
• File Type:
  [PDF - 165.15 KB ]