Ambient Temperature and Risk of First Primary Basal Cell Carcinoma: A Nationwide United States Cohort Study

Details

• Personal Author:
  Alexander BH ; Cahoon EK ; Freedman DM ; Kitahara CM ; Linet MS ; Little MP ; Neta G
• Description:
  The Earth's surface is warming and animal studies have shown higher temperatures promote ultraviolet radiation (UVR) skin carcinogenesis. There are, however, no population studies of long-term temperature exposure and basal cell carcinoma (BCC) risk. We linked average lifetime summer ambient temperatures (based on weather station data) and satellite-based UVR estimates to self-reported lifetime residences in the U.S. Radiologic Technologists' cohort. We assessed the relationship between time-dependent average lifetime summer ambient temperature (20-year lag) in quintiles and BCC in whites, using Cox proportional hazards regression. Risks were adjusted for time-dependent lagged average lifetime UVR and time outdoors, body mass index, eye color, and sex (baseline hazard stratified on birth cohort). During a median 19.4 years follow-up, we identified 3556 BCC cases. There was no significant trend in risk between temperature and BCC. However, BCC risk was highest in the fourth quintile of temperature (Q4 vs. Q1; hazards ratio (HR) = 1.18; 95% confidence interval (CI) = 1.06-1.31, p-trend = 0.09). BCC risk was strongly related to average lifetime ambient UVR exposure (Q5 vs. Q1; HR = 1.54 (95% CI = 1.35-1.75, p-trend = <0.001)). Future studies of temperature and BCC risk should include a broad range of UVR and temperature values, along with improved indicators of exposure to temperatures and UVR. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Epidemiology Neoplasms Occupational Health Safety Skin Skin Diseases Temperature
• Keywords:
  Cancer Rates Carcinomas Cohort Studies Seasonal Factors Skin Cancer Temperature Effects Ultraviolet Radiation
• ISSN:
  1011-1344
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Minnesota ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  284-289
• Volume:
  148
• NIOSHTIC Number:
  nn:20064296
• Citation:
  J Photochem Photobiol B 2015 Jul; 148:284-289
• Contact Point Address:
  D. Michal Freedman, 9609 Medical Center Drive, 7E358, Rockville, MD 20850, USA
• Email:
  freedmam@mail.nih.gov
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Minnesota Twin Cities
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Photochemistry and Photobiology B: Biology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cb49e33885988425c15d285d1d96707387ecbbef77674f4ba94ab20286d4ff1b1b79fe42e7519050a618a28ba3aa32d707468bed7e87b7a044991106b9029535
• Download URL:
  https://stacks.cdc.gov/view/cdc/222788/cdc_222788_DS1.pdf
• File Type:
  [PDF - 227.93 KB ]