Prospective Study of Gamma’ Fibrinogen and Incident Venous Thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology (LITE)

Details

• Personal Author:
  Cushman M ; Folsom AR ; George KM ; Heckbert SR ; MacLehose RF ; Pankow JS ; Tang W
• Description:
  Introduction: Epidemiological studies generally have not found plasma total fibrinogen to be a risk factor for venous thromboembolism (VTE), but several have reported associations between variants in the fibrinogen gamma gene (FGG) and VTE. A case-control study in whites suggested plasma γ' fibrinogen concentration may be associated inversely with VTE, but this was not replicated in African Americans. Objective: To examine the prospective association between γ' fibrinogen concentrations and occurrence of VTE. Methods: We used the Longitudinal Investigation of Thromboembolism Etiology (LITE), involving two pooled population-based cohorts in the United States including 16,234 participants. The cohorts comprised white and African American men and women, aged 50 years and older at study onset in the early 1990s. We identified VTEs during follow-up and documented they met standardized diagnostic criteria. Results: During two decades of follow-up, neither γ' fibrinogen nor total fibrinogen nor their ratio was associated with VTE overall (n = 521 VTEs), in subgroups defined by race, or in other subgroups. In both race groups, the minor allele of FGG rs2066865 was associated with lower γ' fibrinogen concentrations, but this allele was not associated with VTE. Conclusions: A lower plasma concentration of γ' fibrinogen in healthy adults does not appear to increase VTE risk. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Epidemiology Occupational Health Safety
• Keywords:
  Author Keywords: Venous Thrombosis Blood Clots Cardiovascular Disease Cardiovascular System Disorders Fibrinogen Fibrinogen Gamma Heart Disease Longitudinal Study Population Based Studies Prospective Study Pulmonary Embolus

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• ISSN:
  0049-3848
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Minnesota ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 5 ; Vermont ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  44-49
• Volume:
  139
• NIOSHTIC Number:
  nn:20064287
• Citation:
  Thromb Res 2016 Mar; 139:44-49
• Contact Point Address:
  Aaron R. Folsom, Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454, United States
• Email:
  folso001@umn.edu
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of Minnesota Twin Cities
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Thrombosis Research
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8c1c669335a90b6e53f9d270ed55e05864452501ec1b5b3b3f8c496f996a180cfa5ea2bd68c28122ce02e929a36b6a51a3f968e11c0dd7722de88207cdf6c89b
• Download URL:
  https://stacks.cdc.gov/view/cdc/222780/cdc_222780_DS1.pdf
• File Type:
  [PDF - 280.70 KB ]