U.S. flag An official website of the United States government.
Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

i

Association of Plasma Gamma’ Fibrinogen with Incident Cardiovascular Disease: The Atherosclerosis Risk in Communities (ARIC) Study



Details

  • Personal Author:
  • Description:
    Objectives- To prospectively examine the association of plasma γ' fibrinogen with the incidence of multiple cardiovascular disease (CVD) end points, independent of established CVD risk factors, total fibrinogen, and other inflammatory markers. Approach and Results- The Atherosclerosis Risk in Communities (ARIC) study measured γ' fibrinogen by enzyme-linked immunosorbent assay in stored plasma samples from 1993 to 1995 and related levels in 10 601 adults to incident CVD end points (coronary heart disease [n=1603], ischemic stroke [n=548], peripheral artery disease [n=599], heart failure [n=1411], and CVD mortality [n=705]) through 2012 (median follow-up, 18 years). In Cox models accounting for established CVD risk factors and total fibrinogen levels, γ' fibrinogen was associated positively with peripheral artery disease (hazard ratio [HR] per 1-SD [8.80 mg/dL] increment, 1.14 [1.04-1.24]), heart failure (HR, 1.06 [1.01-1.13]), and CVD deaths (HR, 1.12 [1.04-1.21]) but not with incident coronary heart disease (HR, 1.01 [0.96-1.07]) or ischemic stroke (HR, 0.98 [0.89-1.07]). Additional adjustment for C-reactive protein, however, eliminated the associations with peripheral artery disease and heart failure. Conclusions- These findings do not lend support to the hypothesis that γ' fibrinogen influences CVD events through its prothrombotic properties. Rather, γ' fibrinogen concentrations seem to reflect general inflammation that accompanies and may contribute to atherosclerotic CVD, instead of γ' fibrinogen being a causal risk factor. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    1079-5642
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    35
  • Issue:
    12
  • NIOSHTIC Number:
    nn:20064267
  • Citation:
    Arterioscler Thromb Vasc Biol 2015 Dec; 35(12):2700-2706
  • Contact Point Address:
    Duke Appiah, PhD, Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 2nd St, Suite 300, Minneapolis, MN 55454
  • Email:
    dappiah@umn.edu
  • Federal Fiscal Year:
    2016
  • Performing Organization:
    University of Minnesota Twin Cities
  • Peer Reviewed:
    True
  • Start Date:
    20050701
  • Source Full Name:
    Arteriosclerosis, Thrombosis, and Vascular Biology
  • End Date:
    20250630
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:76aadfdbd8995e30b1bb349d634886ec8ac2d0ba3978c51ffdfd172edb843797b37e53924eff9d54e4fc41d8bc2b09f8eb8610f2d355888446d03146ce60dcb9
  • Download URL:
  • File Type:
    Filetype[PDF - 546.96 KB ]
PREVIOUS
ON THIS PAGE
Details
CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
BACK TO TOP