Relationship Between Ambient Ultraviolet Radiation and Non-Hodgkin Lymphoma Subtypes: A U.S. Population-Based Study of Racial and Ethnic Groups

Details

• Personal Author:
  Alexander BH ; Arhancet J ; Cahoon EK ; Freedman DM ; Lin S-W ; Linet MS ; Pfeiffer RM ; Wheeler DC
• Description:
  Associations between ultraviolet radiation (UVR) exposure and non-Hodgkin lymphoma (NHL) have been inconsistent, but few studies have examined these associations for specific subtypes or across race/ethnicities. We evaluated the relationship between ambient UVR exposure and subtype-specific NHL incidence for whites, Hispanics and blacks in the United States for years 2001-2010 (n = 187,778 cases). Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated for UVR quintiles using Poisson regression. Incidence was lower for the highest UVR quintile for chronic/small lymphocytic/leukemia (CLL/SLL) (IRR = 0.87, 95% CI: 0.77-0.97), mantle cell (IRR = 0.82, 95% CI: 0.69-0.97), lymphoplasmacytic (IRR = 0.58, 95% CI: 0.42-0.80), mucosa-associated lymphoid tissue (MZLMALT) (IRR = 0.74, 95% CI: 0.60-0.90), follicular (FL) (IRR = 0.76, 95% CI: 0.68-0.86), diffuse large B-cell (IRR = 0.84, 95% CI: 0.76-0.94;), peripheral T-cell other (PTCL) (IRR = 0.76, 95% CI: 0.61-0.95) and PTCL not otherwise specified (PNOS) (IRR = 0.77, 95% CI: 0.61-0.98). Trends were significant for MZLMALT, FL, DLBCL, BNOS and PTCL, with FL and DLBCL still significant after Bonferroni correction. We found interaction by race/ethnicity for CLL/SLL, FL, Burkitt, PNOS and MF/SS, with CLL/SLL and FL still significant after Bonferroni correction. Some B-cell lymphomas (CLL/SLL, FL and Burkitt) suggested significant inverse relationships in whites and Hispanics, but not in blacks. Some T-cell lymphomas suggested the most reduced risk for the highest quintile of UVR among blacks (PNOS and MF/SS), though trends were not significant. These findings strengthen the case for an inverse association of UVR exposure, support modest heterogeneity between NHL subtypes and suggest some differences by race/ethnicity. [Description provided by NIOSH]
• Subjects:
  Epidemiology Neoplasms Occupational Exposure Occupational Health Race Factors Safety Skin
• Keywords:
  Author Keywords: Ultraviolet Radiation Cancer Rates Chronic Exposure Lymphatic Cancer Non-Hodgkin Lymphoma Population Based Studies Race Racial Factors Sunburns Ultraviolet Radiation
• ISSN:
  0020-7136
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Maryland ; Minnesota ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 8 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  136
• Issue:
  5
• NIOSHTIC Number:
  nn:20064284
• Citation:
  Int J Cancer 2015 Mar; 136(5):E432-E441
• Contact Point Address:
  Elizabeth K. Cahoon, PhD, Radiation Epidemiology Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room7E560, MSC 9778, Bethesda, MD 20892-9778, USA
• Email:
  khaykin@hotmail.com
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Minnesota Twin Cities
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  International Journal of Cancer
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c36002d56a8ac1702986a22b16d3d42bedc08f20ed921b3f2512913868af9d56ad317397eead39449ace279b9521cf3812241c08d977d99319672975a0ee80b6
• Download URL:
  https://stacks.cdc.gov/view/cdc/222778/cdc_222778_DS1.pdf
• File Type:
  [PDF - 257.64 KB ]