Estimation of the Dose of Electronic Cigarette Chemicals Deposited in Human Airways Through Passive Vaping

Details

• Personal Author:
  Buu A ; Chen JY ; Lee J ; Lin Y-H ; Su W-C ; Wong S-W
• Description:
  Background: Existing studies on the health effects of e-cigarettes focused on e-cigarette users themselves. To study the corresponding effects on passive vapers, it is crucial to quantify e-cigarette chemicals deposited in their airways. Objective: This study proposed an innovative approach to estimate the deposited dose of e-cigarette chemicals in the passive vapers' airways. The effect of the distance between active and passive vapers on the deposited dose was also examined. Methods: The chemical constituent analysis was conducted to detect Nicotine and flavoring agents in e-cigarette aerosol. The Mobile Aerosol Lung Deposition Apparatus (MALDA) was employed to conduct aerosol respiratory deposition experiments in real-life settings to generate real-time data. Results: For e-cigarette aerosol in the ultrafine particle regime, the deposited doses in the alveolar region were on average 3.2 times higher than those in the head-to-TB airways, and the deposited dose in the passive vaper's airways increased when being closer to the active vaper. Significance: With prolonged exposure and close proximity to active vapers, passive vapers may be at risk for potential health effects of harmful e-cigarette chemicals. The methodology developed in this study has laid the groundwork for future research on exposure assessment and health risk analysis for passive vaping. [Description provided by NIOSH]
• Subjects:
  Aerosols Flavoring Agents Lung Nicotine Occupational Health Respiratory System Safety Smokers Solvents Tobacco Products
• Keywords:
  Aerosol Author Keywords: E-cigarette Chemical Deposition Cigarette Smoking Deposited Dose Direct-reading Methods Dose Response Exposure Assessment Flavorings Human Airways Pulmonary System Respiratory Deposition Vapors

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• ISSN:
  1559-0631
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 6 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  31
• Issue:
  6
• NIOSHTIC Number:
  nn:20064200
• Citation:
  J Expo Sci Environ Epidemiol 2021 Nov; 31(6):1008-1016
• Contact Point Address:
  Wei-Chung Su, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA
• Email:
  Wei-Chung.Su@uth.tmc.edu
• CAS Registry Number:
  (-)-Nicotine (CAS RN 54-11-5)
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of Texas Health Science Center, Houston
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Exposure Science and Environmental Epidemiology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8e9ec548cba7e4efc5e71796ecbec35fc36e2cc62f611be58d46d9d8058bc41fd90bccd3deaed44cbef68133392c13c771d3f57407ae05eeacfcfdcb53517153
• Download URL:
  https://stacks.cdc.gov/view/cdc/222705/cdc_222705_DS1.pdf
• File Type:
  [PDF - 1.16 MB ]