Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Blouin, Yann ; Cazajous, Géraldine ; Dehan, Céline ; Soler, Charles ; Vong, Rithy ; ... More +
Blouin, Yann ; Cazajous, Géraldine ; Dehan, Céline ; Soler, Charles ; Vong, Rithy ; Hassan, Mohamed Osman ; Hauck, Yolande ; Boulais, Christian ; Andriamanantena, Dina ; Martinaud, Christophe ; Martin, Émilie ; Pourcel, Christine ; Vergnaud, Gilles Less -
Description:
“Mycobacterium canettii,” an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacterium tuberculosis emerged. Since its discovery in 1969, most of the ≈70 known M. canettii strains were isolated in the Republic of Djibouti, frequently from expatriate children and adults. We show here, by whole-genome sequencing, that most strains collected from February 2010 through March 2013, and associated with 2 outbreaks of lymph node tuberculosis in children, belong to a unique epidemic clone within M. canettii. Evolution of this clone, which has been recovered regularly since 1983, may mimic the birth of M. tuberculosis. Thus, recognizing this organism and identifying its reservoir are clinically important.
Subject:
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Adolescent
Adult
Biosynthetic Pathways
Child
Child, Preschool
Cluster Analysis
Clustered Regularly Interspaced Short Palindromic Repeats
Female
Genome, Bacterial
Humans
Infant
Male
Middle Aged
Mycobacterium/classification
Mycobacterium/genetics
Mycobacterium/metabolism
Phylogeny
Polymorphism, Single Nucleotide
Research
Tuberculosis, Lymph Node/epidemiology
Tuberculosis, Lymph Node/microbiology
Vitamin B 12/biosynthesis
Young Adult

Source:
Emerg Infect Dis. 20(1):21-28.
Document Type:
Journal Article
Place as Subject:
Djibouti
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:31d430c89528b4c5ebdb294a9da766b5a5c7369b0f80fb7037ee087582ed4396
File Type:

Supporting Files

• 	license.txt	txt
  	13-0652-F1.gif	gif
  	13-0652-F1.jpg	jpeg
  	13-0652-F2.gif	gif
  	13-0652-F2.jpg	jpeg
  	13-0652-Techapp-s1.pdf	pdf
  	13-0652-Techapp-s2.xlsx	xlsx
  	13-0652.nxml	txt

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