Toenail Manganese as a Potential Biomarker for In Utero and Early Childhood Exposure Studies

Details

• Personal Author:
  Choudhary K ; Cigan SS ; Georgieff M ; McGovern, Patricia M. ; Miller, Nadia C. ; Rao R ; Stepanov I
• Description:
  Elevated in utero and early childhood exposure to manganese may have adverse effects on neurodevelopment. We conducted preliminary analyses to evaluate toenails as a matrix for investigating manganese exposure in infants. Infant and maternal toenail and hair samples were collected from 25 infants (7 months old) and their mothers. A subset of mothers was recruited in the third trimester of pregnancy and some also provided pre-natal toenail, hair, and blood samples, cord blood, and additional post-natal samples. Collected samples were analyzed by inductively coupled plasma mass-spectrometry. Toenail manganese levels in infants ranged from below the limit of detection (LOD) to 2.80 µg/g. Only 1 toenail sample and 4 hair samples contained levels of manganese below LOD. Associations between infant and maternal biomarkers were not statistically significant. Analysis of multiple post-natal toenail samples from a single infant-mother pair showed an increase in the infant's toenail manganese and a decrease in maternal toenail manganese over the first year of the infant's life. Overall, our findings suggest that toenails may serve as a valuable biological matrix for measuring manganese exposure in newborns and infants; however, additional studies are needed to determine the impact of the timing of toenail sample collection on its utility in assessing early life exposure and health outcomes. [Description provided by NIOSH]
• Subjects:
  Biomarkers Manganese Occupational Health Pregnancy Safety
• Keywords:
  Biological Monitoring Children Exposure Assessment In Utero Exposure Prenatal Exposure
• ISSN:
  2045-2322
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Minnesota ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  8
• NIOSHTIC Number:
  nn:20064148
• Citation:
  Sci Rep 2018 Nov; 8:17034
• Contact Point Address:
  Irina Stepanov, School of Public Health, Division of Environmental Health Sciences, University of Minnesota, Minneapolis, MN, 55455, USA
• Email:
  stepa011@umn.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Minnesota Twin Cities
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Scientific Reports
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d6baaea3fed8f16fcf43dd7cd375744575b9e6cbb52bf48fae64485fbbaba0b27ed2a7fa02e971f7b8bff3aeeac2b23c6c7ef9aa9a87924131891802d7984158
• Download URL:
  https://stacks.cdc.gov/view/cdc/222656/cdc_222656_DS1.pdf
• File Type:
  [PDF - 1.78 MB ]