Autoimmune Conditions in the World Trade Center General Responder Cohort: A Nested Case-Control and Standardized Incidence Ratio Analysis

Details

• Personal Author:
  Carson D ; Cohen BL ; Cooney ML ; Crane MA ; Crowson C ; Dasaro CR ; Davies TF ; Haber RS ; Hahn CJ ; Harrison DJ ; Hirten RP ; Luft BJ ; Moline JM ; Sacks HS ; Shapiro MZ ; Simpson DM ; Sloan NL ; Smirnoff M ; Tassiulas I ; Teitelbaum SL ; Todd AC ; Udasin IG
• Description:
  Background: The World Trade Center (WTC) general responder cohort (GRC) was exposed to environmental toxins possibly associated with increased risk of developing autoimmune conditions. Objectives: Two study designs were used to assess incidence and risks of autoimmune conditions in the GRC. Methods: Three clinically trained professionals established the status of possible GRC cases of autoimmune disorders adhering to diagnostic criteria, supplemented, as needed, by specialists' review of consenting responders' medical records. Nested case-control analyses using conditional logistic regression estimated the risk associated with high WTC exposure (being in the 9/11/2001 dust cloud or =median days' response worked) compared with low WTC exposure (all other GRC members'). Four controls were matched to each case on age at case diagnosis (+/- 2 years), sex, race/ethnicity, and year of program enrollment. Sex-specific and sensitivity analyses were performed. GRC age- and sex-adjusted standardized incidence ratios (SIRs) were compared with the Rochester Epidemiology Project (REP). Complete REP inpatient and outpatient medical records were reviewed by specialists. Conditions meeting standardized criteria on >=2 visits were classified as REP confirmed cases. Results: Six hundred and twenty-eight responders were diagnosed with autoimmune conditions between 2002 and 2017. In the nested case-control analyses, high WTC exposure was not associated with autoimmune domains and conditions (rheumatologic domain odds ratio [OR] = 1.03, 95% confidence interval [CI] = 0.77, 1.37; rheumatoid arthritis OR = 1.12, 95% CI = 0.70, 1.77). GRC members had lower SIR than REP. Women's risks were generally greater than men's. Conclusions: The study found no statistically significant increased risk of autoimmune conditions with WTC exposures. [Description provided by NIOSH]
• Subjects:
  Dust Emergency Responders Environmental Exposure Epidemiology Hazardous Substances Men Occupational Health Race Factors Risk Assessment Risk Factors Safety September 11 Terrorist Attacks Women

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• Keywords:
  Author Keywords: World Trade Center Autoimmune Conditions Autoimmune Diseases Dust Exposure Dusts Environmental Exposure Exposure Levels First Responders Humans Medical Records Racial Factors Responder/Recovery Worker Risk Factors Toxins World Trade Center WTC

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Contract ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Minnesota ; New Jersey ; New York ; Ohio ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  117-131
• Volume:
  65
• Issue:
  2
• NIOSHTIC Number:
  nn:20064060
• Citation:
  Am J Ind Med 2022 Feb; 65(2):117-131
• Contact Point Address:
  Nancy L. Sloan, DrPH, and Susan L. Teitelbaum, PhD, Department of Environmental Medicine and Public Health, Icahn School of Medicineat Mount Sinai, Box 1057, New York,, NY 10029, USA
• Email:
  nancy.sloan@mssm.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  State University of New York Stony Brook
• Peer Reviewed:
  True
• Start Date:
  20040715
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20110630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c7bdccc695530429cd14c0e7a18594060519a18e826579131ac9b307f338ca9500d484f36a605deaa30237ebc3c61100bdb2ca224b0c7310fb8f0606322c9cfc
• Download URL:
  https://stacks.cdc.gov/view/cdc/222586/cdc_222586_DS1.pdf
• File Type:
  [PDF - 1.01 MB ]