Source Apportionment and Quantification of Liquid and Headspace Leaks from Closed System Drug-Transfer Devices via Selected Ion Flow Tube Mass Spectrometry (SIFT-MS)

Details

• Personal Author:
  Doepke A ; Streicher, Robert P.
• Description:
  A system to differentiate and quantify liquid and headspace vapor leaks from closed system drug-transfer devices (CSTDs) is presented. CSTDs are designed to reduce or eliminate hazardous drug (HD) exposure risk when compounding and administering HDs. CSTDs may leak liquid, headspace, or a mixture of the two. The amount of HD contained in liquid and headspace leaks may be substantially different. Use of a test solution containing two VOCs with differences in ratios of VOC concentrations in the headspace and liquid enables source apportionment of leaked material. SIFT-MS was used to detect VOCs from liquid and headspace leaks in the vapor phase. Included in this report is a novel method to determine the origin and magnitude of leaks from CSTDs. A limit of leak detection of 24 µL of headspace vapor and 0.14 µL of test liquid were found using Selected Ion Flow Tube Mass Spectrometry (SIFT-MS). [Description provided by NIOSH]
• Subjects:
  Drug Therapy Hazardous Substances Occupational Health Safety Solvents
• Keywords:
  Drug Therapy Hazardous Drugs Leak Detectors Mass Spectrometry Medicinal Chemicals Vapors
• ISSN:
  1932-6203
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  11
• NIOSHTIC Number:
  nn:20063986
• Citation:
  PLoS One 2021 Nov; 16(11):e0258425
• Contact Point Address:
  Amos Doepke, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Chemical and Biochemical Monitoring Branch, Alice Hamilton Laboratories, Cincinnati, Ohio, United States
• Email:
  adoepke@cdc.gov
• Federal Fiscal Year:
  2022
• Peer Reviewed:
  True
• Source Full Name:
  PLoS One
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6b870c6e1036d7acf14ebebf015f287e11ec27ec27ef04322892a227905ea7ffe1b61b6746ed2b3ac344df5f2fa1ee7598404c94f3f9f11e2cb70db8230c8bca
• Download URL:
  https://stacks.cdc.gov/view/cdc/222515/cdc_222515_DS1.pdf
• File Type:
  [PDF - 2.26 MB ]