Idiopathic Pulmonary Fibrosis: Unmasking Cryptogenic Environmental Factors

Details

• Personal Author:
  Raghu G ; Sack C
• Description:
  Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown origin that is associated with high morbidity and mortality. In this perspective, we briefly review the current understanding of the pathophysiology of IPF and the importance of environmental triggers as a precipitant of disease. We discuss occult intrinsic and extrinsic environmental factors that affect the lung microenvironment and may contribute to the development and progression of disease. The clinical implications of this framework need to be further elucidated, because prompt identification and elimination of occult exposures may represent a novel treatment modality. [Description provided by NIOSH]
• Subjects:
  Environment Environmental Exposure Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Environmental Exposure Environmental Factors Lung Fibrosis Pathogenesis Physiological Effects Physiopathology Pulmonary Disorders
• ISSN:
  0903-1936
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  53
• Issue:
  2
• NIOSHTIC Number:
  nn:20063869
• Citation:
  Eur Respir J 2019 Feb; 53(2):1801699
• Contact Point Address:
  Ganesh Raghu, Center for Interstitial Lung Disease, University of Washington, Seattle, WA 98195, USA
• Email:
  graghu@uw.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  European Respiratory Journal
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b30f41fc55bdba0b90f44934e921ba8f9872b5d65ea0ecbad5830db4a8eb735572786034a9b26e28de518dcf946e556795c4a10a8f712fdaf9cdcdf84ac89d9f
• Download URL:
  https://stacks.cdc.gov/view/cdc/222412/cdc_222412_DS1.pdf
• File Type:
  [PDF - 345.87 KB ]