Environmental Causes of Idiopathic Pulmonary Fibrosis

Details

• Personal Author:
  Gandhi S ; Murray M ; Samarelli AV ; Spagnolo P ; Tonelli R
• Description:
  Idiopathic pulmonary fibrosis (IPF), the most common and severe of the idiopathic interstitial pneumonias, is a chronic and relentlessly progressive disease, which occurs mostly in middle-aged and elderly males. Although IPF is by definition "idiopathic", multiple factors have been reported to increase disease risk, aging being the most prominent one. Several occupational and environmental exposures, including metal dust, wood dust and air pollution, as well as various lifestyle variables, including smoking and diet, have also been associated with an increased risk of IPF, probably through interaction with genetic factors. Many of the predisposing factors appear to act also as trigger for acute exacerbations of the disease, which herald a poor prognosis. The more recent literature on inhalation injuries has focused on the first responders in the World Trade Center attacks and military exposure. In this review, we present an overview of the environmental and occupational causes of IPF and its pathogenesis. While our list is not comprehensive, we have selected specific exposures to highlight based on their overall disease burden. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Lung Lung Diseases Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Idiopathic Pulmonary Fibrosis Environmental Exposure Environmental Exposures Interstitial Lung Disease Lung Disease Lung Fibrosis Occupational Exposure Occupational Exposures Pathogenesis Pulmonary Disorders
• ISSN:
  1422-0067
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  24
• Issue:
  22
• NIOSHTIC Number:
  nn:20069688
• Citation:
  Int J Mol Sci 2023 Nov; 24(22):16481
• Contact Point Address:
  Paolo Spagnolo, Respiratory Disease Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy
• Email:
  paolo.spagnolo@unipd.it
• Federal Fiscal Year:
  2024
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  International Journal of Molecular Sciences
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:df197201de5e02dbf0ca16cb398efba89bcd96aa265304e09b3f0fe7fbc67c375ce4c5f81e8ccfe7060ecf1f8b187968de1c12796eea62d705c8a681b7d7e9e4
• Download URL:
  https://stacks.cdc.gov/view/cdc/208065/cdc_208065_DS1.pdf
• File Type:
  [PDF - 1.10 MB ]