Ambient Air Pollution and Pulmonary Vascular Volume on Computed Tomography: The MESA Air Pollution and Lung Cohort Studies

Details

• Personal Author:
  Aaron CP ; Austin JHM ; Barr RG ; Budoff M ; Hinckley Stukovsky K ; Hoffman EA ; Kaufman JD ; Kawut SM ; Michos ED ; Sack C ; Szpiro AA ; Watson KD
• Description:
  Background: Air pollution alters small pulmonary vessels in animal models. We hypothesised that long-term ambient air pollution exposure would be associated with differences in pulmonary vascular volumes in a population-based study. Methods: The Multi-Ethnic Study of Atherosclerosis recruited adults in six US cities. Personalised long-term exposures to ambient black carbon, nitrogen dioxide (NO2), oxides of nitrogen (NOx), particulate matter with a 50% cut-off aerodynamic diameter of <2.5 µm (PM2.5) and ozone were estimated using spatiotemporal models. In 2010-2012, total pulmonary vascular volume was measured as the volume of detectable pulmonary arteries and veins, including vessel walls and luminal blood volume, on noncontrast chest computed tomography (TPVVCT). Peripheral TPVVCT was limited to the peripheral 2 cm to isolate smaller vessels. Linear regression adjusted for demographics, anthropometrics, smoking, second-hand smoke, renal function and scanner manufacturer. Results: The mean +/- sd age of the 3023 participants was 69.3 +/- 9.3 years; 46% were never-smokers. Mean exposures were 0.80 µg·m-3 black carbon, 14.6 ppb NO2 and 11.0 µg·m-3 ambient PM2.5. Mean +/- sd peripheral TPVVCT was 79.2 +/- 18.2 cm3 and TPVVCT was 129.3 +/- 35.1 cm3. Greater black carbon exposure was associated with a larger peripheral TPVVCT, including after adjustment for city (mean difference 0.41 (95% CI 0.03-0.79) cm3 per interquartile range; p=0.036). Associations for peripheral TPVVCT with NO2 were similar but nonsignificant after city adjustment, while those for PM2.5 were of similar magnitude but nonsignificant after full adjustment. There were no associations for NOx or ozone, or between any pollutant and TPVVCT. Conclusions: Long-term black carbon exposure was associated with a larger peripheral TPVVCT, suggesting diesel exhaust may contribute to remodelling of small pulmonary vessels in the general population. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cohort Studies Lung Nitrogen Dioxide Occupational Health Particulate Matter Respiratory System Safety
• Keywords:
  Air Pollution Cohort Studies Diesel Exhaust Health Effects Nitrogen Dioxide Nitrogen Oxides Particulates Population Based Studies Pulmonary Effects
• ISSN:
  0903-1936
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Iowa ; Maryland ; New York ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 7 ; OSHA Region 9 ; Pennsylvania ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  53
• Issue:
  6
• NIOSHTIC Number:
  nn:20063838
• Citation:
  Eur Respir J 2019 Jun; 53(6):1802116
• Contact Point Address:
  Carrie P. Aaron, Dept of Medicine, College of Physicians and Surgeons, Columbia University, PH 9 East Room 105, 630 West 168th Street, New York, NY 10032-3784, USA
• Email:
  cp2346@columbia.edu
• CAS Registry Number:
  Nitrogen dioxide (CAS RN 10102-44-0)
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  European Respiratory Journal
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:56c962ba4a627b08eab2a36e5b9007c4e949e730853e33926f606fc9c461f6270525e37aabf8fc3672ad0d9a6c8adf1af05471003a4cc0728b630b41bc0435c4
• Download URL:
  https://stacks.cdc.gov/view/cdc/222385/cdc_222385_DS1.pdf
• File Type:
  [PDF - 1.76 MB ]