An Ultra Low-Cost Smartphone Device for In-Situ Monitoring of Acute Organophosphorus Poisoning for Agricultural Workers

Details

• Personal Author:
  Bhalli JA ; Chang Y-C ; Du D ; Ge X ; Khalid ZM ; Khan QM ; Lee SS ; Li L ; Lin Y ; Paulsen MH ; Simpson CD ; Waheed U ; Wang L-J
• Description:
  In this work, we present an ultra-low-cost smartphone device for in situ quantification of OP poisoning severity. The performance of the lens-less smartphone spectrum apparatus (LeSSA) is evaluated using standard human Interleukin-6 (IL-6) immunoassay kits. Upon dose-response curve fitting, LeSSA demonstrates an accuracy of 99.5%. The limit of detection (LOD) of LeSSA was evaluated through comparison of 6.4 pg/ml with standard laboratory grade UV-vis spectrophotometer at 5.5 pg/ml. Evaluating the capacity of LeSSA in spike solution by combining plasma cholinesterase (PChE) and human plasma shows consistency at agreement of 97.6% between LeSSA and the laboratory instrument. For application demonstration, the activity of PChE for 24 agricultural workers' plasma samples was measured with LeSSA, showing exceptional agreement (r2 = 0.92) with the laboratory instrument reference. In addition to near laboratory grade accuracy, the total manufacturing cost of LeSSA is only $20 USD highlighting it's affordability. With LeSSA, clinicians can evaluate OP poisoning severity without the need to transport patient samples to facilities at far distances. Utilizing LeSSA, immediate results can be used for administration of appropriate treatment. [Description provided by NIOSH]
• Subjects:
  Computers Manufacturing And Industrial Facilities Mining Occupational Health Safety Software
• Keywords:
  Agriculture Author Keywords: Organophosphorus Poisoning Cell Phones Diagnostic Techniques Mobile Device Mobile Equipment Organophosphorus Compounds Pesticides And Agricultural Chemicals Point-of-care Diagnostics Sensors
• ISSN:
  0925-4005
• Document Type:
  Text
• Funding:
  Grant ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Idaho ; OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  300-305
• Volume:
  275
• NIOSHTIC Number:
  nn:20063817
• Citation:
  Sens Actuators B Chem 2018 Dec; 275:300-305
• Contact Point Address:
  Lei Li, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA
• Email:
  lei.li2@wsu.edu
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  Washington State University
• Peer Reviewed:
  True
• Start Date:
  20150901
• Source Full Name:
  Sensors and Actuators B: Chemical
• End Date:
  20180831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8f01cf77080a0615b9c82595b6c32411887b9bf57e5093f1076700f265caae16b379a25ffa90379bd7986487dbacda2e39e04a409282eb79a7399e1a9eba09ee
• Download URL:
  https://stacks.cdc.gov/view/cdc/222369/cdc_222369_DS1.pdf
• File Type:
  [PDF - 1.09 MB ]