Portable X-Ray Fluorescence as a Rapid Determination Tool to Detect Parts per Million Levels of Ni, Zn, as, Se, and Pb in Human Toenails: A South India Case Study

Details

• Personal Author:
  Balcom P ; Bhatia M ; Konda M ; Qureshi A ; Ramya V ; Specht AJ ; Sulaiman D ; Sunderland EM
• Description:
  Chronic exposure to inorganic pollutants adversely affects human health. Inductively coupled plasma mass spectrometry (ICP-MS) is the most common method used for trace metal(loid) analysis of human biomarkers. However, it leads to sample destruction, generation of secondary waste, and significant recurring costs. Portable X-ray fluorescence (XRF) instruments can rapidly and nondestructively determine low concentrations of metal(loid)s. In this work, we evaluated the applicability of portable XRF as a rapid method for analyzing trace metal(loid)s in toenail samples from three populations (n = 97) near the city of Chennai, India. A Passing-Bablok regression analysis of results from both methods revealed that there was no proportional bias among the two methods for nickel (measurement range approx. 25 to 420 mg/kg), zinc (10 to 890 mg/kg), and lead (0.29 to 4.47 mg/kg). There was a small absolute bias between the two methods. There was a strong proportional bias (slope = 0.253, 95% CI: 0.027, 0.614) between the two methods for arsenic (below detection to 3.8 mg/kg) and for selenium when the concentrations were lower than 2 mg/kg. Limits of agreement between the two methods using Bland-Altman analysis were derived for nickel, zinc, and lead. Overall, a suitably calibrated and evaluated portable XRF shows promise in making high-throughput assessments at population scales. [Description provided by NIOSH]
• Subjects:
  Biomarkers Metals Metals, Heavy Occupational Health Safety
• Keywords:
  Analytical Methods Author Keywords: Portable XRF Heavy Metals High Correlation ICP-MS Limit Of Detection LOD Metal Compounds Metalloids Mobile Equipment Toenails X-ray Fluorescence Analysis

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• ISSN:
  0013-936X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; Massachusetts ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  55
• Issue:
  19
• NIOSHTIC Number:
  nn:20063764
• Citation:
  Environ Sci Technol 2021 Oct; 55(19):13113-13121
• Contact Point Address:
  Aaron J. Specht, School of Health Sciences, Purdue University, West Lafayette, Indiana 47906, United States
• Email:
  aspecht@purdue.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2) ; Lead (CAS RN 7439-92-1) ; Nickel (CAS RN 7440-02-0) ; Selenium (CAS RN 7782-49-2) ; Zinc (CAS RN 7440-66-6)
• Federal Fiscal Year:
  2022
• NORA Priority Area:
  Construction ; Manufacturing
• Performing Organization:
  Harvard School of Public Health, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  20190901
• Source Full Name:
  Environmental Science and Technology
• End Date:
  20220831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:21eb9b737801d839de0859178f582a598cb52327acbe5f5cac9ef47fe97eb01c43b9630300626b0ee888a51f2e60ef6a9605dfff7b6fa8eaa33bf8c82480a35e
• Download URL:
  https://stacks.cdc.gov/view/cdc/222320/cdc_222320_DS1.pdf
• File Type:
  [PDF - 1.12 MB ]