Maternal Body Burden of Cadmium and Offspring Size at Birth

Details

• Personal Author:
  Checkoway, Harvey ; Enquobahrie DA ; Romano ME ; Simpson C ; Williams MA
• Description:
  Increasing evidence suggests an inverse association between cadmium (Cd) and size at birth, potentially greatest among female neonates. We evaluated whether greater maternal body burden of Cd is associated with reduced neonatal anthropometry (birthweight, birth length, head circumference, and ponderal index) and assessed whether these associations differ by infant sex. The analytic sample for the present study (n=396) was derived from a subcohort of 750 women randomly drawn from among all participants (N=4344) in the Omega Study, a prospective pregnancy cohort. Creatinine-corrected Cd in maternal clean-catch spot urine samples (U-Cd) was quantified by inductively coupled plasma mass spectrometry. Continuous log2-transformed Cd (log2-Cd) and U-Cd tertiles (low<0.29 µg/g creatinine, middle 0.29-0.42 µg/g creatinine, high=0.43 µg/g creatinine) were used in multivariable linear regression models. Females had reduced birth length with greater U-Cd tertile, whereas males birth length marginally increased [beta(95% CI) females: low=reference, middle=-0.59 cm (-1.37, 0.19), high=-0.83 cm (-1.69, 0.02), p-trend=0.08; males: low=reference, middle=0.18 cm (-0.59, 0.95), high=0.78 cm (-0.04, 1.60), p-trend=0.07; p for interaction=0.03]. The log2-Cd by infant sex interaction was statistically significant for ponderal index [p=0.003; beta(95% CI): female=0.25 kg/m3 (-0.20, 0.70); male=-0.63 kg/m3 (-1.01, -0.24)] and birth length [p<0.001; beta(95% CI): female=-0.47 cm (-0.74, -0.20), male=0.32 cm (0.00, 0.65)]. Our findings suggest potential sex-specific reversal of Cd's associations on birth length and contribute to the evidence suggesting Cd impairs fetal growth. [Description provided by NIOSH]
• Subjects:
  Cadmium Cohort Studies Epidemiology Infant, Newborn Occupational Health Pregnancy Safety Sex Characteristics
• Keywords:
  Cohort Studies Neonates Prenatal Exposure Sex Factors
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Massachusetts ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 9 ; Rhode Island ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  461-468
• Volume:
  147
• NIOSHTIC Number:
  nn:20063735
• Citation:
  Environ Res 2016 May; 147:461-468
• Contact Point Address:
  Megan E. Romano; Department of Epidemiology, Box G-S121-2, Brown University, Providence, RI 02903, USA
• Email:
  megan_romano@brown.edu
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9)
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f8dc0ca5882d103a001361f2d7d1840a4664fdaa98f31d5812e4741cbe9fb2657cebd430d220aeb9e924b6c89ebf811f9d54d6fb9ec174d8799cfbd05cc37084
• Download URL:
  https://stacks.cdc.gov/view/cdc/222295/cdc_222295_DS1.pdf
• File Type:
  [PDF - 375.50 KB ]